, Volume 106, Issue 3, pp 297–305 | Cite as

Current knowledge among Japanese experienced general dentists regarding prevention of infective endocarditis

  • Ryota Nomura
  • Kazuma Kokomoto
  • Takahiro Ohara
  • Satoshi Nakatani
  • Takashi Ooshima
  • Kazuhiko Nakano
Original Article


Infective endocarditis (IE), a life-threatening condition predominantly occurring in patients with underlying heart disease, is mainly caused by bacteremia induced by invasive dental treatment. However, the amount of related information shared between cardiologists and dentists appears to be inadequate. In the present study, a survey regarding prevention of IE, composed of 13 major questions, 2 of which also allowed free comments, was sent to approximately 3000 dentists belonging to a prefectural dental association in Japan. Of the 13.6% who returned the forms, more than 80% were general dentists with more than 20 years of experience. Approximately, 55% of the responders reported that they had opportunities to prescribe antibiotics prior to performing treatments with risk of IE, though noted difficulties with designation of which patients with heart disease were at risk. Most of the dentists considered that oral surgery procedures have a high risk for IE, whereas less invasive procedures were considered to be not associated with the disease. Approximately, 35% selected oral amoxicillin, with a dose of 2.0 g (20%) or 500 mg (27%) prescribed for adults, and 50 mg (10%) or 30 mg (12%) per kg of body weight for children. However, the timing of the antibiotics administration varied. The present results reveal current knowledge regarding prevention of IE among general dentists in Japan, and should be valuable for construction of a protocol to establish consensus between dentists and cardiologists.


Infective endocarditis Dentists Prevention Antibiotics Japan 



The authors express their appreciation to the Hyogo Dental Association (President: Dr. Takashi Sawada) for helping with distribution of the present survey to their members.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study protocol was approved by the Ethics Committee of Osaka University Graduate School of Dentistry (Approval No.: H28-E23).


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Copyright information

© The Society of The Nippon Dental University 2018

Authors and Affiliations

  • Ryota Nomura
    • 1
  • Kazuma Kokomoto
    • 1
  • Takahiro Ohara
    • 2
  • Satoshi Nakatani
    • 3
  • Takashi Ooshima
    • 1
  • Kazuhiko Nakano
    • 1
  1. 1.Division of Oral Infection and Disease ControlOsaka University Graduate School of DentistrySuitaJapan
  2. 2.Division of Community MedicineTohoku Medical and Pharmaceutical UniversitySendaiJapan
  3. 3.Division of Functional Diagnostics, Department of Health SciencesOsaka University Graduate School of MedicineSuitaJapan

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