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Odontology

, Volume 106, Issue 3, pp 232–237 | Cite as

Na18F accumulates on the compressive side of peri-implant bone under immediate loading

  • Miou Yamamoto
  • Toru Ogawa
  • Masayoshi Yokoyama
  • Yoshihito Funaki
  • Kenta Shobara
  • Aya Shibamoto
  • Juan Ramón Vanegas Sáenz
  • Keiichi Sasaki
Original Article

Abstract

This study aimed to examine the dynamic change in bone metabolism by immediate loading in several sites around implants using high-resolution Na18F-PET scan. Two titanium implants (Ø 1.2 mm) were inserted parallel to each other in the right tibiae of Wistar rats (n = 4). The left tibia was set as control side. One day after insertion, closed coil springs of 4.0 N were attached to the expose superior portions of the implants to apply a continuous mechanical stress. The rats with fluorine-18 (18F) ion (5 mCi/rat) intravenously injected were scanned by PET scanner at 4, 7, 14, 28 days after load application. Round region of interests (ROIs) were set around the distal implant of the right tibia (loaded side) and same site (control) of the left tibia. Furthermore, four rectangular ROIs were set at the superior and inferior parts of traction side (mesial) and opposite side (distal) of the distal implant. Longitudinal dynamic changes in bone metabolism were evaluated by examination of the accumulation count of 18F ion at each ROI. The uptake values of ROIs (loaded side) initially increased until 7 days, and they gradually decreased from the peak level to the pre-loading level despite a static force being applied to the implants. In cancellous bone, the uptake values at the superior part of traction side and inferior part of opposite side showed significantly high value compared with those at other parts. In conclusion, immediate loading to the implant initially enhanced bone metabolism around it, especially at the part with compressive stress. Peri-implant bone metabolism varies according to different loading conditions.

Keywords

Bone metabolism Peri-implant bone Na18F-PET Immediate loading Animal study 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Funding

This work was partially supported by Grants-in-Aid for Scientific Research (B) (Grant no. 24390428), Grant-in-Aid for Young Scientists (B) (Grant no. 24792130, 26861620) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

Ethical approval

This article does not contain any studies with human participants. Ethical approval (2012CrA-4) was provided by the Institutional Animal Use and Care Committee of Tohoku University.

Informed consent

For this type of study, formal consent is not required.

References

  1. 1.
    Weber HP, Morton D, Galluci GO, Roccuzzo M, Cordaro L, Grutter L. Consensus statements and recommended clinical procedures regarding loading protocols. Int J Oral Maxillofac Implants. 2009;24:180–3.PubMedGoogle Scholar
  2. 2.
    Esposito M, Grusovin MG, Maghaireh H, Worthington HV. Interventions for replacing missing teeth: different times for loading dental implants. Cochrane Database Syst Rev. 2013;28(3):CD003878.Google Scholar
  3. 3.
    Alsabeeha N, Atieh M, Payne AG. Loading protocols for mandibular implant overdentures: a systematic review with meta-analysis. Clin Implant Dent Relat Res. 2010;12:e28–38.CrossRefPubMedGoogle Scholar
  4. 4.
    Javed F, Romanos GE. The role of primary stability for successful immediate loading of dental implants. A literature review J Dent. 2010;38:612–20.PubMedGoogle Scholar
  5. 5.
    Yoda N, Zheng K, Chen J, Li W, Swain M, Sasaki K, Li Q. Bone morphological effects on post-implantation remodeling of maxillary anterior buccal bone: a clinical and biomechanical study. J Prosthodont Res. 2017;61(4):393–402.  https://doi.org/10.1016/j.jpor.2016.12.010.CrossRefPubMedGoogle Scholar
  6. 6.
    Ogawa T, Zhang X, Naert I, Vermaelen P, Deroose CM, Sasaki K, et al. The effect of whole-body vibration on peri-implant bone healing in rats. Clin Oral Implants Res. 2011;22:302–7.CrossRefPubMedGoogle Scholar
  7. 7.
    Hoh CK, Hawkins RA, Dahlbom M, Glaspy JA, Seeger LL, Choi Y, et al. Whole body skeletal imaging with [18F] fluoride ion and PET. J Comput Assist Tomogr. 1993;17:34–41.CrossRefPubMedGoogle Scholar
  8. 8.
    Blau M, Ganatra R, Bender MA. 18F-fluoride for bone imaging. Semin Nucl Med. 1972;2:31–7.CrossRefPubMedGoogle Scholar
  9. 9.
    Grant FD, Fahey FH, Packard AB, Davis RT, Alavi A, Treves ST. Skeletal PET with 18F-fluoride: applying new technology to an old tracer. J Nucl Med. 2008;49:68–78.CrossRefPubMedGoogle Scholar
  10. 10.
    Ishii K, Kikuchi Y, Matsuyama S, Kanai Y, Kotani K, Ito T, et al. First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner. Nucl Instrum Methods Phys Res A. 2007;576:435–40.CrossRefGoogle Scholar
  11. 11.
    Matsuo Y, Ogawa T, Yamamoto M, Shibamoto A, Sáenz JR, Yokoyama M, et al. Evaluation of peri-implant bone metabolism under immediate loading using high-resolution Na18F-PET. Clin Oral Investig. 2017;21:2029–37.CrossRefPubMedGoogle Scholar
  12. 12.
    Yamamoto M, Ogawa T, Tokoyama M, Koyama S, Sasaki K. Influence of immediate and early loading on bone metabolic activity around dental implants in rat tibiae. Clin Oral Impl Res. 2014;25:1084–90.CrossRefGoogle Scholar
  13. 13.
    Gentleman E, Stevens MM, Hill RG, Brauer DS. Surface properties and ion release from fluoride-containing bioactive glasses promote osteoblast differentiation and mineralization in vitro. Acta Biomater. 2013;9:5771–9.CrossRefPubMedGoogle Scholar
  14. 14.
    Shepp LA, Vardi Y. Maximum likelihood reconstruction for emission tomography. IEEE Trans Med Imaging. 1982;1:113–22.CrossRefPubMedGoogle Scholar
  15. 15.
    Bambini F, Memè L, Procaccini M, Rossi B, LO Muzio L. Bone scintigraphy and SPECT in the evaluation of the osseointegrative response to immediate prosthetic loading of endosseous implants: a pilot study. Int J Oral Maxillofac Implants. 2004;19:80–6.PubMedGoogle Scholar
  16. 16.
    Yokohama M, Atsumi T, Tsuchiya M, Koyama S, Sasaki K. Dynamic changes in bone metabolism in the rat temporomandibular joint after molar extraction using bone scintigraphy. Eur J Oral Sci. 2009;117:374–9.CrossRefGoogle Scholar
  17. 17.
    Suenaga H, Yokohama M, Yamaguchi K, Sasaki K. Bone metabolism of residual ridge beneath the denture base of an RPD observed using NaF-PET/CT. J Prosthodont Res. 2012;56:42–6.CrossRefPubMedGoogle Scholar
  18. 18.
    Temmerman OP, Raijmakers PG, Heyligers IC, Comans EF, Lubberink M, Teule GJ, et al. Bone metabolism after total hip revision surgery with impacted grafting: evaluation using H215O and [18F] fluoride PET; a pilot study. Mol Imaging Biol. 2008;10:288–93.CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Sasaki H, Koyama S, Yokoyama M, Yamaguchi K, Itoh M, Sasaki K. Bone metabolic activity around dental implants under loading observed using bone scintigraphy. Int J Oral Maxillofac Implants. 2008;23:827–34.PubMedGoogle Scholar

Copyright information

© The Society of The Nippon Dental University 2017

Authors and Affiliations

  • Miou Yamamoto
    • 1
  • Toru Ogawa
    • 1
  • Masayoshi Yokoyama
    • 1
  • Yoshihito Funaki
    • 2
  • Kenta Shobara
    • 1
  • Aya Shibamoto
    • 1
  • Juan Ramón Vanegas Sáenz
    • 1
  • Keiichi Sasaki
    • 1
  1. 1.Division of Advanced Prosthetic DentistryTohoku University Graduate School of DentistrySendaiJapan
  2. 2.Cyclotron and Radioisotope CenterTohoku UniversitySendaiJapan

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