, Volume 105, Issue 1, pp 1–12 | Cite as

Collagen based barrier membranes for periodontal guided bone regeneration applications

  • Zeeshan Sheikh
  • Javairia Qureshi
  • Abdullah M. Alshahrani
  • Heba Nassar
  • Yuichi Ikeda
  • Michael Glogauer
  • Bernhard GanssEmail author
Review Article


Certain cell populations within periodontal tissues possess the ability to induce regeneration, provided they have the opportunity to populate the wound or defect. Guided regeneration techniques have been investigated for regenerating periodontal tissues and such therapies usually utilize barrier membranes. Various natural and synthetic barrier membranes have been fabricated and tested to prevent epithelial and connective tissue cells from invading while allowing periodontal cells to selectively migrate into the defect. This paper focuses on the literature relevant to the use and potential of resorbable collagen membranes in GBR procedures, sites of periodontal and intrabony defects, in cases of socket and alveolar ridge preservation and at implant sites. The results of their use in GBR procedures has shown them to be effective and comparable with non-resorbable membranes with regards to clinical attachment gain, probing depth reduction and defect bone filling. They have also shown to prevent epithelial ingrowth into the defect space during the initial wound healing phase postsurgically. Collagen membranes have also been used for root coverage and GBR procedures and have shown good success rates comparable to subepithelial connective tissue grafts and expanded-polytetrafluoroethylene (e-PTFE) membranes. The future for periodontal tissue engineering is very exciting with the use of barrier membranes expected to continue playing a critical role. However, long-term clinical trials are required to further evaluate and confirm the efficacy of the available collagen barrier membranes for periodontal and bone regeneration use.


Collagen Barrier membranes Periodontal regeneration GBR GTR 



A special thanks to the following people for helping and contributing towards this article: Ms. Esraa Khalil, Amman, Jordan for providing with the illustrations for Fig. 1; Dr. Thomas T. Nguyen, Assistant Professor in Periodontics, Faculty of Dentistry, University of Montreal, Canada for providing the clinical photographs for Fig. 2; of Dr. Nader Hamdan, Periodontist, Canada for providing the clinical photographs for Figs. 3 and 4; and Dr. Faisal Qayyum, Consultant Prosthodontist, Aga Khan University Hospital for providing the clinical photographs for Fig. 5.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© The Society of The Nippon Dental University 2016

Authors and Affiliations

  1. 1.Matrix Dynamics Group, Faculty of DentistryUniversity of TorontoTorontoCanada
  2. 2.Lunenfeld-Tanenbaum Research InstituteMt. Sinai HospitalTorontoCanada
  3. 3.Smile Point Dental PracticeKarachiPakistan
  4. 4.Alfarabi Dental CollegeRiyadhKingdom of Saudi Arabia
  5. 5.Fairmont Dental GroupVancouverCanada

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