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Systems biology approaches to abscisic acid signaling

Journal of Plant Research volume 124, pages 539–548 (2011)Cite this article

Abstract

Recent advances in our understanding of abscisic acid (ABA) signaling have identified a core pathway consisting of receptors (PYR/PYL/RCAR), protein phosphatases (PP2C), protein kinases (SnRK2), and several downstream factors that will lead to the next stage of ABA research. Systems biology will be an important concept for further understanding ABA responses in plants. In this review, two practical approaches of systems biology to ABA signaling are presented: the one is ‘transcriptome analysis’, which covers coding genes as well as unannotated transcripts, and the other is ‘phosphoproteomics’. The latter technology will offer an unprecedented overview of the regulatory networks involved in ABA signaling because protein phosphorylation/dephosphorylation is a major center of such regulation. Systematic studies will contribute to our understanding of the network structure and dynamics of ABA signaling; moreover, systems biology will facilitate ABA signaling studies as well as future biotechnological applications in crops or trees.

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Acknowledgments

I express my deepest gratitude for Dr. Kazuo Shinozaki (RIKEN). I thank Dr. Takashi Hirayama (Okayama Univ.), Dr. Yasushi Ishimaha (Kyoto Univ.), Dr. Naoyuki Sugiyama (Keio Univ.) and other lab members for their support and collaboration, and also thank Dr. Kazuyuki Kuchitsu (Tokyo Univ. Sci.) and Dr. Eiji Nambara (Univ. Toronto) for their helpful comments and discussions about the manuscript. Our study was partly supported by a Grant-in-Aid for Young Scientists (B) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan, by the Strategic Programs for R&D (President’s Discretionary Fund) from RIKEN, and by the Program for the Promotion of Basic Research Activities for Innovative Biosciences (BRAIN) of Japan.

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  1. Gene Discovery Research Group, RIKEN Plant Science Center, 3-1-1 Kouyadai, Tsukuba, Ibaraki, 305-0074, Japan

    Taishi Umezawa

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  1. Taishi Umezawa
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Correspondence to Taishi Umezawa.

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Umezawa, T. Systems biology approaches to abscisic acid signaling. J Plant Res 124, 539–548 (2011). https://doi.org/10.1007/s10265-011-0418-x

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  • DOI: https://doi.org/10.1007/s10265-011-0418-x

Keywords

  • Abscisic acid (ABA)
  • Signal transduction
  • Systems biology
  • Phosphoproteomics
  • Next generation sequencing