Abstract
In recent years regenerative techniques, such as autologous chondrocyte implantation (ACI), have emerged as a potential therapeutic option for the treatment of chondral lesions. However, the good results reported have to be weighed against the number of problems that can be observed with the standard ACI methods. To address these problems, the so-called second generation ACI techniques have been developed. Autologous chondrocyte transplantation on a three-dimentional matrix was introduced in clinical practice from 1998–1999 and results at short-medium term follow up is well documented for different types of scaffold. These techniques may be used for the treatment of large chondral lesions in the young active population and highly competitive athletes, but long-term and randomized controlled studies will be needed to confirm reliability of these procedures. Several improvements are soon expected, as the result of the rapidly growing knowledge on cell culture and chondrocyte behaviour, leading to a more reliable surgical technique and better clinical outcome.
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Kon, E., Altadonna, G., Balboni, F. et al. “Scaffold” nel trattamento delle lesioni condrali. Arch Ortop Reumatol 120, 21–22 (2009). https://doi.org/10.1007/s10261-009-0045-4
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DOI: https://doi.org/10.1007/s10261-009-0045-4