Abstract.
In this study we characterized a model of human peritoneal macrophages maintained in culture for up to 48 h that can be used to study different functions of this cell population in vitro. The cells remained viable and functionally active over time, with well-preserved phagocytic properties. They expressed a macrophage marker, CD14. Once in culture, human peritoneal macrophages secreted C1q and nitric oxide in a pattern described in murine, guinea pig, and rat peritoneal macrophages . The described model can be used to study physiology and pathophysiology of peritoneal macrophages in vitro, offering all the advantages of the use of a human cell population.
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Received: 8 November 2002 / Accepted: 11 February 2003
Correspondence to D. Faust
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Faust, D., Akoglu, B., Faust, A. et al. Human peritoneal macrophages in culture: a model for studying inflammatory disorders in vitro. Clin Exp Med 3, 15–19 (2003). https://doi.org/10.1007/s102380300010
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DOI: https://doi.org/10.1007/s102380300010