Fig. 5
From: CDKN1A and cellular senescence are associated with immune resistance in advanced lung adenocarcinoma
Clinical significance of CDKN1A and senescence genes. A The distinct CDKN1A expression patterns between patients with control disease (CR + PR + SD) and progressive disease (PD) treated with immunotherapy. The CDKN1A groups (upper panel) and the expression of CDKN1A (bottom panel) between response categories were visualized, respectively. CR, complete response; PR, Partial response; SD, Stable disease. B Kaplan–Meier survival curves between diverse CDKN1A expression groups in advanced LUAD for both SU2C-MARK and TCGA cohorts. OS, overall survival; PFS, progression free survival; PFI, progression free interval. C Forest plots of univariable Cox analysis for senescence genes with significant resistance of immunotherapy for OS