Fig. 2
From: CDKN1A and cellular senescence are associated with immune resistance in advanced lung adenocarcinoma
Systemic analysis of biological characteristics of CDKN1A in advanced LUAD (TCGA cohort). A–B The enriched biological gene sets in CDKN1A high (A) versus low (B) expression groups. C The representative cell types with associations of the expression of CDKN1A. MSC_cell, mesenchymal stem cell; CLP, common lymphoid progenitor; ly endothelial cells, lymphatic endothelial cells; mv endothelial cells, microvascular endothelial cells; aDC, activated dendritic cell; iDC, immature dendritic cell. D Multivariable analysis for OS incorporating the CDKN1A-by-CD8AB interaction term (Hazard = a × CDKN1A + b × CD8 + c × CDKN1A × CD8). The coefficient c reflects the effect of interaction between the expression of CDKN1A and CD8 on death hazard estimated from the survival data. CD8AB, the average expression of CD8A and CD8B. E–F The Spearman correlation between the expression of CDKN1A and the cancer-associated fibroblasts (CAFs, E) score and myeloid-derived suppressor cells (MDSCs, F) score