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Ménière’s disease and allergy: Epidemiology, pathogenesis, and therapy

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Abstract

The etiology of Ménière’s disease (MD) remains controversial. Allergies are potential extrinsic factors that, in conjunction with underlying intrinsic factors, may cause MD. The link between allergies and MD was first described in 1923. For nearly a century, studies have demonstrated a possible link between allergies and MD, even though a causal relationship has not been definitively determined. Previous reviews have mainly focused on clinical epidemiology studies of patients. In this review, we shed light on the association between allergies and MD not only in terms of its epidemiology, but also from an immunology, pathophysiology, and immunotherapy perspective in both patients and animal models. Patients with MD tend to have a high risk of comorbid allergies or an allergy history, showing positive allergy immunology characteristics. Other MD-related diseases, such as migraine, may also interact with allergies. Allergy mediators such as IgE may worsen the symptoms of MD. Deposits of IgE in the vestibular end organs indicate the ability of the inner ear to participate in immune reactions. Allergic challenges can induce vertigo in animals and humans. Anti-allergy therapy plays a positive role in patients with MD and animal models of endolymphatic hydrops.

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Funding

This work was supported by the Major Program of National Natural Science Foundation of China (Grant number 82196821), Major Fundamental Research Program of the Natural Science Foundation of Shandong Province, China (Grant number ZR2021ZD40), the Taishan Scholar Foundation of Shandong Province (Grant number ts20130913), the National Natural Science Foundation of China (Grant numbers 82171150, 82101225, 82371154, 82101226 and 82271172), and the Natural Science Foundation of Shandong Province (Grant numbers ZR2020MH179 and ZR2021MH385).

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HW had the idea for the article, NZ, JL, GL and YLyu performed the literature search, XL, YS, LK performed data analysis, Z.F provided suggestions, WX drafted the work, DZ and NL supervised and critically revised the work. All authors permit the submission of the study.

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Correspondence to Daogong Zhang, Haibo Wang or Na Li.

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Xu, W., Li, X., Song, Y. et al. Ménière’s disease and allergy: Epidemiology, pathogenesis, and therapy. Clin Exp Med 23, 3361–3371 (2023). https://doi.org/10.1007/s10238-023-01192-0

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