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The role of mast cells in human skin cancers

Clinical and Experimental Medicine volume 21, pages 355–360 (2021)Cite this article

Abstract

Mast cells (MCs) are immune cells derived from myeloid lineage present in all classes of vertebrates and have emerged preceding much time the development of adaptive immunity. MCs are involved in inflammatory processes, allergic reactions, and host responses to parasites and bacteria infectious diseases. MCs are located at the host-environment interface, at many sites of initial antigen entry, including skin, lung and gastrointestinal tract, and have part of a protective mechanism. Skin has an important role in protecting the host from invasion both as physical barriers and by employing an intricate network of resident immune and non-immune cells include macrophages, T and B lymphocytes, MCs, neutrophils, eosinophils, and Langerhans cells. In this review we discussed the role of MCs in human skin cancers.

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Affiliations

  1. Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Policlinico - Piazza G. Cesare, 11, 70124, Bari, Italy

    Domenico Ribatti, Roberto Tamma & Tiziana Annese

  2. Department of Medicine, Section of Human Anatomy, University of Udine, Udine, Italy

    Enrico Crivellato

Authors
  1. Domenico Ribatti
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  2. Roberto Tamma
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  3. Tiziana Annese
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  4. Enrico Crivellato
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DR involved in conceptualization, conceived the study and wrote the ms; RT, TA and EC involved in revise and editing the ms.

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Correspondence to Domenico Ribatti.

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Ribatti, D., Tamma, R., Annese, T. et al. The role of mast cells in human skin cancers. Clin Exp Med 21, 355–360 (2021). https://doi.org/10.1007/s10238-021-00688-x

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  • DOI: https://doi.org/10.1007/s10238-021-00688-x

Keywords

  • Basal cell carcinoma
  • Mast cells
  • Mastocytosis
  • Melanoma
  • Squamous cell carcinoma