Skip to main content

Decreased serum myonectin concentrations in diabetic nephropathy patients

Clinical and Experimental Medicine volume 20, pages 601–607 (2020)Cite this article

Abstract

Myonectin is a newly discovered myokine correlated with diabetes. Diabetic nephropathy (DN), which is diagnosed according to albuminuria, is one of the most common microvascular complications of diabetes. Albuminuria predisposes to future cardiovascular diseases and mortality. The aim of this study is to assess the association between serum myonectin concentrations with DN. A total of 188 patients with type 2 diabetes (T2DM) and 66 control subjects were enrolled in this investigation. T2DM patients were divided into three groups: normoalbuminuria (n = 84), microalbuminuria (n = 70), and macroalbuminuria (n = 34) according to urine albumin-to-creatinine ratio (ACR). T2DM patients showed lower serum myonectin concentrations compared with the controls. Serum myonectin concentrations were significantly decreased in macroalbuminuria group than in normoalbuminuria and microalbuminuria groups. In addition, microalbuminuria group had decreased serum myonectin concentrations compared with normoalbuminuria group. Logistic regression analysis demonstrated a correlation between serum myonectin and a decreased risk of T2DM and DN. Simply linear regression analysis indicated serum myonectin was negatively correlated body mass index (BMI), total cholesterol, low-density lipoprotein cholesterol, blood urea nitrogen, creatinine, uric acid, and ACR, and positively correlated with glomerular filtration rate, insulin treatment. BMI, ACR, and insulin treatment were still correlated with the serum myonectin after a multiple linear regression analysis. Our investigation indicates serum myonectin is decreased in DN patients and correlated with renal function.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

Fig. 1

Data availability

Data are available upon reasonable request.

References

  1. Jansson SP, Fall K, Brus O, et al. Prevalence and incidence of diabetes mellitus: a nationwide population-based pharmaco-epidemiological study in Sweden. Diabet Med. 2015;32:1319–28.

    CAS  Article  Google Scholar 

  2. Souweine JS, Corbel A, Rigothier C, et al. Interest of albuminuria in nephrology, diabetology and as a marker of cardiovascular risk. Ann Biol Clin (Paris). 2019;77:26–35.

    Google Scholar 

  3. Uchida J, Machida Y, Iwai T, et al. Low-grade albuminuria reduction with angiotensin II type 1 receptor blocker in renal transplant recipients. J Nephrol. 2011;24:515–21.

    CAS  Article  Google Scholar 

  4. Perkovic V, Verdon C, Ninomiya T, et al. The relationship between proteinuria and coronary risk: a systematic review and meta-analysis, Version 2. PLoS Med. 2008;5:e207.

    Article  Google Scholar 

  5. Kakio Y, Uchida HA, Takeuchi H, et al. Diabetic nephropathy is associated with frailty in patients with chronic hemodialysis. Geriatr Gerontol Int. 2018;18:1597–602.

    Article  Google Scholar 

  6. Eppens MC, Craig ME, Cusumano J, et al. Prevalence of diabetes complications in adolescents with type 2 compared with type 1 diabetes. Diabetes Care. 2006;29:1300–6.

    Article  Google Scholar 

  7. Yan ST, Liu JY, Tian H, Li CL, Li J, Shao YH, Shi HY, Liu Y, Gong YP, Fang FS, Sun BR. Clinical and pathological analysis of renal damage in elderly patients with type 2 diabetes mellitus. Clin Exp Med. 2016;16:437–42.

    Article  Google Scholar 

  8. Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 2012;287:11968–80.

    CAS  Article  Google Scholar 

  9. Lim S, Choi SH, Koo BK, et al. Effects of aerobic exercise training on C1q tumor necrosis factor α-related protein isoform 5 (myonectin): association with insulin resistance and mitochondrial DNA density in women. J Clin Endocrinol Metab. 2012;97:E88–93.

    CAS  Article  Google Scholar 

  10. Li Z, Yang YL, Zhu YJ, et al. Circulating serum myonectin levels in obesity and type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes; 2019 Jul 24.

  11. Li K, Liao X, Wang K, et al. Myonectin predicts the development of type 2 diabetes. J Clin Endocrinol Metab. 2018;103:139–47.

    Article  Google Scholar 

  12. Zhang Y, Liu C, Liu J, et al. Implications of C1q/TNF-related protein superfamily in patients with coronary artery disease. Sci Rep. 2020;10:878.

    Article  Google Scholar 

  13. ShokoohiNahrkhalaji A, Ahmadi R, Fadaei R, Panahi G, Razzaghi M, Fallah S. Higher serum level of CTRP15 in patients with coronary artery disease is associated with disease severity, body mass index and insulin resistance. Arch Physiol Biochem. 2019. https://doi.org/10.1080/13813455.2019.1675713.

    Article  Google Scholar 

  14. Otaka N, Shibata R, Ohashi K, et al. Myonectin is an exercise-induced myokine that protects the heart from ischemia-reperfusion injury. Circ Res. 2018;123:1326–38.

    CAS  Article  Google Scholar 

  15. Sun YM, Su Y, Li J, Wang LF. Recent advances in understanding the biochemical and molecular mechanism of diabetic nephropathy. Biochem Biophys Res Commun. 2013;433:359–61.

    CAS  Article  Google Scholar 

  16. VasanthRao VR, Tan SH, Candasamy M, Bhattamisra SK. Diabetic nephropathy: an update on pathogenesis and drug development. Diabetes Metab Syndr. 2019;13:754–62.

    Article  Google Scholar 

  17. Aghadavod E, Khodadadi S, Baradaran A, Nasri P, Bahmani M, Rafieian-Kopaei M. Role of oxidative stress and inflammatory factors in diabetic kidney disease. Iran J Kidney Dis. 2016;10:337–43.

    PubMed  Google Scholar 

  18. Barutta F, Bruno G, Grimaldi S, Gruden G. Inflammation in diabetic nephropathy: moving toward clinical biomarkers and targets for treatment. Endocrine. 2015;48:730–42.

    CAS  Article  Google Scholar 

  19. Peterson JM, Mart R, Bond CE. Effect of obesity and exercise on the expression of the novel myokines, myonectin and fibronectin type III domain containing 5. PeerJ. 2014;2:e605.

    Article  Google Scholar 

  20. Little HC, Rodriguez S, Lei X, et al. Myonectin deletion promotes adipose fat storage and reduces liver steatosis. FASEB J. 2019;33:8666–87.

    CAS  Article  Google Scholar 

Download references

Funding

No funding.

Author information

Author notes

  1. Jie Zhang and Wenchao Hu have contributed equally to this article. Correspondence to Peng Lin and Rui Wang.

Affiliations

  1. Department of Medical Imaging, NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, People’s Republic of China

    Jie Zhang

  2. Department of Endocrinology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, People’s Republic of China

    Wenchao Hu

  3. Department of Endocrinology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 West Wenhua Road, Jinan, 250012, Shandong, People’s Republic of China

    Peng Lin

  4. Department of Blood Transfusion, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Shibei District, Qingdao, 266035, Shandong, People’s Republic of China

    Rui Wang

Authors
  1. Jie Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wenchao Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peng Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Rui Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Peng Lin or Rui Wang.

Ethics declarations

Conflict of interest

The authors declare that there is no conflict of interest regarding the publication of this article.

Ethics approval

This study was approved by the Ethics Board of Qilu Hospital of Shandong University (Qingdao).

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zhang, J., Hu, W., Lin, P. et al. Decreased serum myonectin concentrations in diabetic nephropathy patients. Clin Exp Med 20, 601–607 (2020). https://doi.org/10.1007/s10238-020-00654-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10238-020-00654-z

Keywords

  • Myonectin
  • Diabetic nephropathy
  • Albumin-to-creatinine ratio