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Intermedin ameliorates IgA nephropathy by inhibition of oxidative stress and inflammation

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Abstract

IgA nephropathy (IgAN) is the most frequent form of glomerulonephritis worldwide. The role of oxidative stress and inflammation in the pathogenesis of IgAN has been reported. Intermedin (IMD) is a newly discovered peptide that is closely related to adrenomedullin. We have recently reported that IMD can significantly reduce renal ischemia/reperfusion injury by diminishing oxidative stress and suppressing inflammation. The present study was designed to explore whether IMD ameliorates IgAN via oxidative stress- and inflammation-dependent mechanisms. Our results showed that IMD administration resulted in the prevention of albuminuria and ameliorated renal pathomorphological changes. These findings were associated with (1) decreased renal TGF-β1 and collagen IV expression, (2) an increased SOD level and reduced MDA level, (3) the inhibition of the renal activation of NF-κB p65 and (4) the downregulation of the expression of inflammatory factors (TNF-α, MCP-1 and MMP-9) in the kidney. These results indicate that IMD in the kidney protects against IgAN by reducing oxidative stress and suppressing inflammation.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant No. 30971380), the Doctoral Startup Research Fund of Shanxi Medical University (03201302), the Science and Technology Innovation Fund of Shanxi Medical University (01201403) and 331 fund projects of Basic Medical College, Shanxi Medical University (201406).

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    Authors and Affiliations

    1. Department of Microbiology and Immunology, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China

      Yanhong Wang, Jihua Tian, Haixiu Guo & Yang Mi

    2. Department of Nephrology, The Affiliated People’s Hospital of Shanxi Medical University, Shanxi Provincial People’s Hospital, Shanxi Kidney Disease Institute, No. 29 Shuang Ta East Street, Taiyuan, 030012, Shanxi, People’s Republic of China

      Ruijing Zhang & Rongshan Li

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    Correspondence to Rongshan Li.

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    Jihua Tian have contributed to this work.

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    Wang, Y., Tian, J., Guo, H. et al. Intermedin ameliorates IgA nephropathy by inhibition of oxidative stress and inflammation. Clin Exp Med 16, 183–192 (2016). https://doi.org/10.1007/s10238-015-0351-8

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