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Structural changes in α1-adrenoceptor antagonist-treated human prostatic stroma

Clinical and Experimental Medicine volume 10, pages 99–106 (2010)Cite this article

Abstract

α1-Adrenoceptor antagonists (α1-blockers) are currently used as first-line drugs for the treatment of benign prostatic hyperplasia (BPH). However, cases of BPH are often encountered in which the efficacy of α1-blockers decreases and switching to surgical treatment is required. One factor responsible for this resistance includes structural changes in prostatic tissue architecture following repeated oral administration of α1-blockers. Forty patients suspected of having prostate cancer, but without evidence of malignancy on prostatic biopsy were divided into two groups: an untreated group (n = 17) and an oral α1-blocker-treated group (n = 23). Twenty-one patients exhibiting resistance to oral α1-blocker therapy who underwent surgery were assigned into the surgically treated group. Each tissue sample was subjected to Masson’s trichrome staining to distinguish collagen fibers from smooth muscle constituting prostatic stroma. The mean collagen fiber share was 62.2 ± 10.4% in the untreated group, 72.1 ± 9.1% in the oral α1-blocker-treated group, and 72.2 ± 15.7% in the surgically treated group. Focusing on cases exhibiting high-collagen fiber share (70% or more), the distribution in each of the two α1-blocker-treated groups (16 of the 23 cases from the oral α1-blocker-treated group and 10 of the 21 cases from the surgically treated group) differed significantly from that in the untreated group (2 of the 17 cases). Our findings suggest that the accumulation of collagen fibers in prostatic stroma could be one of the factors responsible for α1-blocker treatment.

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Acknowledgments

This study was financially supported by Grants-in-Aid from the Ministry of Education for Science and Culture of Japan (Nos. 18591748, 19591841, and 19659412). The authors thank the physicians working at Suzuka Chuou General Hospital, Mie Chuou Medical Center, Saiseikai Matsusaka General Hospital, Mie Prefectural General Medical Center, and Takeuchi Hospital, who are members of the Mie Clinical Urologic Research Entry (M-CURE) and supplied tissue specimens for this study. The authors also thank Mrs. Hiroko Nishii for her support in histopathological analysis.

Conflict of interest statement

The authors declare that they have no conflict of interest related to the publication of this manuscript.

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Affiliations

  1. Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Tetsuya Imamura, Kenichiro Ishii, Hideki Kanda, Shigeki Arase, Yuko Yoshio, Yasuhide Hori, Norihito Soga, Hideaki Kise, Kiminobu Arima & Yoshiki Sugimura

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  1. Tetsuya Imamura
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  2. Kenichiro Ishii
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  3. Hideki Kanda
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  4. Shigeki Arase
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  5. Yuko Yoshio
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  6. Yasuhide Hori
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  7. Norihito Soga
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  8. Hideaki Kise
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  9. Kiminobu Arima
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  10. Yoshiki Sugimura
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Corresponding author

Correspondence to Yoshiki Sugimura.

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T. Imamura and K. Ishii contributed equally to this work.

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Imamura, T., Ishii, K., Kanda, H. et al. Structural changes in α1-adrenoceptor antagonist-treated human prostatic stroma. Clin Exp Med 10, 99–106 (2010). https://doi.org/10.1007/s10238-009-0073-x

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  • DOI: https://doi.org/10.1007/s10238-009-0073-x

Keywords

  • α1-Adrenoceptor antagonist
  • Benign prostatic hyperplasia
  • Prostatic tissue architecture
  • Collagen fiber
  • Morphometrical analysis