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Dimethylarginines and inflammation markers in patients with chronic kidney disease undergoing dialysis

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Abstract

The aim of this study was to investigate the pro-oxidant and proinflammatory biomarkers and their relationship with dimethylarginines (DMAs) in patients at various stages of chronic kidney disease (CKD). We studied 114 CKD patients, 36 were hemodialyzed, 41 peritoneal dialyzed and 37 nondialyzed (early stage) CKD patients. The control group consisted of 31 healthy subjects. Plasma levels of asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), l-arginine, nitric oxide (NO) and proinflammatory cytokines (TNF-alpha and IL-6) were determined, and their relationships with the degree of disease were evaluated. Both DMAs were at high levels in all CKD patients, whereas arginine concentrations were low in patients undergoing dialysis. Elevated TNF-α and IL-6 in CKD patients were indicative of ongoing chronic inflammatory state. A significant positive correlation between SDMA and creatinine suggests that plasma SDMA level may be an index for renal function.

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Acknowledgments

This work was supported by the Research Fund of Istanbul University. Projects: 508/05052006 and BYP-881/06012006.

Conflict of interest statement

The authors declare that they have no conflict of interest related to the publication of this manuscript.

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Authors and Affiliations

  1. Medical Laboratory Programme, Medical Services Training School, Istanbul University, Cerrahpasa, Istanbul, Turkey

    Yildiz Oner-Iyidogan

  2. Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, 34093, Istanbul, Turkey

    Pernur Oner, Hikmet Kocak, Figen Gurdol, Seldag Bekpinar, Yesim Unlucerci & Pinar Cetinalp-Demircan

  3. Department of Nephrology, Istanbul University, Capa, 34093, Istanbul, Turkey

    Yasar Caliskan & Aydin Turkmen

  4. Department of Urology, Istanbul University, Capa, 34093, Istanbul, Turkey

    Taner Kocak

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  1. Yildiz Oner-Iyidogan
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Correspondence to Yildiz Oner-Iyidogan.

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Oner-Iyidogan, Y., Oner, P., Kocak, H. et al. Dimethylarginines and inflammation markers in patients with chronic kidney disease undergoing dialysis. Clin Exp Med 9, 235–241 (2009). https://doi.org/10.1007/s10238-009-0035-3

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  • DOI: https://doi.org/10.1007/s10238-009-0035-3

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