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Myasthenia gravis and the thymus gland. A historical review

Clinical and Experimental Medicine volume 8, pages 61–64 (2008)Cite this article

Abstract

The first report of an association between myasthenia gravis (MG) and the thymus gland was in 1901. Although the underlying mechanisms are uncertain, thymic abnormalities are clearly associated with MG. This review article summarises, from a historical point of view, our knowledge of these associations, and the surgical and medical treatment of MG, including symptom management, immunosuppression, intravenous immunoglobulin and plasmapheresis.

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References

  1. Conti-Fine BM, Protti MP, Bellone M, Howard JF (1997) Myasthenia gravis and its experimental model: the immunobiology of an autoimmune disease. Landes Bioscience Publishers, Georgetown

    Google Scholar 

  2. Weigert C (1901) Pathologisch-anatomischer Beitrag zur Erb’schen Krankheit (Myasthenia gravis). Leipzig, Neurologisches Centralblatt 20:597–601

    Google Scholar 

  3. Kirschner PA (1987) Alfred Blalock and thymectomy for myasthenia gravis. Ann Thoracic Surg 43:348–349

    Article  CAS  Google Scholar 

  4. Blalock A, Mason MP, Morgan HJ, Riven SS (1939) Myasthenia gravis and tumours of the thymic region. Report of a case in which the tumour was removed. Ann Surg 110:544–561

    Article  PubMed  CAS  Google Scholar 

  5. Blalock A, Harvey AM, Ford PR, Lillenthal JL (1941) Treatment of myasthenia gravis by removal of the thymus gland. A preliminary report. J Am Med Assoc 117:1529–1533

    Google Scholar 

  6. Blalock A (1944) Thymectomy in the treatment of myasthenia gravis: report of 20 cases. J Thorac Surg 13:316–339

    Google Scholar 

  7. Kark AE, Papatestas AE (1971) Some anatomic features of the transcervical approach for thymectomy. Mt Sinai J Med 38:580–585

    PubMed  CAS  Google Scholar 

  8. Edgeworth H (1930) A report of progress on the use of ephedrine in a case of myasthenia gravis. JAMA 94:1136.

    Google Scholar 

  9. Boothby WM, Adams M, Power MH et al (1932) Myasthenia gravis: second report on the effect of treatment with glycine. Proc Mayo Clinic 7:737–756

    Google Scholar 

  10. Walker MB (1934) Treatment of myasthenia gravis with physostigmine. Lancet i:1200–1201

    Article  Google Scholar 

  11. Morton LT, Moore RJ (1997) A chronology of medicine and related sciences. Scholar Press, Aldershot

    Google Scholar 

  12. Keesey JC (1998) Contemporary opinions about Mary Walker. A shy pioneer of therapeutic neurology. Neurology 51:1433–1439

    PubMed  CAS  Google Scholar 

  13. Pearce JMS (2005) Mary Broadfoot Walker (1888–1974): a historic discovery in myasthenia gravis. Eur Neurol 53:51–53

    Article  PubMed  CAS  Google Scholar 

  14. Simpson JA (1960) Myasthenia gravis. A new hypothesis. Scotl Med J 5:419–436

    Google Scholar 

  15. Keesey JC (2002) Myasthenia gravis: an illustrated history. Publishers Design Group, Roseville, CA

    Google Scholar 

  16. Howard JF (1999) Myasthenia gravis. Proceedings Myasthenia Gravis Foundation Annual Meeting, pp 1–7

  17. Mack M, Landreneau R, Yim A et al (1996) Results of video-assisted thymectomy in patients with myasthenia gravis. J Thorac Cardiovasc Surg 112:1352–1360

    Article  PubMed  CAS  Google Scholar 

  18. Ashton RC, McGinnis KM, Connery CP et al (2003) Totally endoscopic thymectomy for myasthenia gravis. Ann Thorac Surg 75:569–571

    Article  PubMed  Google Scholar 

  19. Rea F, Bortolott L, Girardi LR, Sartori F (2003) Thoracoscopic thymectomy with the Da Vinci surgical system in patient with myasthenia gravis. Interact Cardiovasc Thorac Surg 2:70–72

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Histology and Cytology “Victor Babes”, University of Medicine and Pharmacy, Timisoara, Romania

    Marius Raica & Anca Maria Cimpean

  2. Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, I-70124, Bari, Italy

    Domenico Ribatti

Authors
  1. Marius Raica
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  2. Anca Maria Cimpean
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  3. Domenico Ribatti
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Correspondence to Domenico Ribatti.

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Raica, M., Cimpean, A.M. & Ribatti, D. Myasthenia gravis and the thymus gland. A historical review. Clin. Exper.Med. 8, 61–64 (2008). https://doi.org/10.1007/s10238-008-0158-y

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  • DOI: https://doi.org/10.1007/s10238-008-0158-y

Keywords

  • History of medicine
  • Myasthenia gravis
  • Thymus gland