Abstract
In order to evaluate whether treatment with valproic acid or carbamazepine can modify interleukins and monocyte chemoattractant protein-1, we studied 40 epileptic children and adolescents. We evaluated the patients before and after 1 year of therapy. At the end of follow-up, the patients showed a significant increase of the production of interleukin-1α, interleukin-1β, interleukin-6, and monocyte chemoattractant protein-1; interleukin-2 production was significantly higher only in patients receiving carbamazepine. In conclusion, antiepileptic drugs can influence the immune system by modifying interleukin and chemokine concentrations; these changes seem to be independent of the serum concentrations of these drugs.
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Received: 16 February 2001 / Accepted: 18 September 2001
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Verrotti, A., Basciani, F., Trotta, D. et al. Effect of anticonvulsant drugs on interleukins-1, -2 and -6 and monocyte chemoattractant protein-1. Clin Exp Med 1, 133–136 (2001). https://doi.org/10.1007/s10238-001-8024-1
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DOI: https://doi.org/10.1007/s10238-001-8024-1