Abstract
Cranial dura mater is a dense interwoven vascularized connective tissue that helps regulate neurocranial remodeling by responding to strains from the growing brain. Previous ex vivo experimentation has failed to account for the role of prestretch in the mechanical behavior of the dura. Here we aim to estimate the prestretch in mouse cranial dura mater and determine its dependency on direction and age. We performed transverse and longitudinal incisions in parietal dura excised from newborn (day \(\sim\)4) and mature (12 weeks) mice and calculated the ex vivo normalized incision opening (measured width over length). Then, similar incisions were simulated under isotropic stretching within Abaqus/Standard. Finally, prestretch was estimated by comparing the ex vivo and in silico normalized openings. There were no significant differences between the neonatal and adult mice when comparing cuts in the same direction, but adult mice were found to have significantly greater stretch in the anterior–posterior direction than in the medial–lateral direction, while neonatal dura was essentially isotropic. Additionally, our simulations show that increasing curvature impacts the incision opening, indicating that flat in silico models may overestimate prestretch.
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Data availablity
Original data (images, measurements, etc.) and scripts to run all simulations and analysis are available at https://github.com/mholla/BMMB24.
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Acknowledgements
This project was supported by NSF Grant Nos. IIS-1850102 (to M. A. Holland) and BCS-1848884 (to M. J. Ravosa), the Indiana Clinical and Translational Sciences Institute (to M. A. Holland, M. J. Ravosa, and C. J. Goergen; funded, in part, by grant no. UL1TR002529 from the NIH National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award), the NIH National Heart, Lung, and Blood Institute (F30-HL145980 to F. W. Damen), and the Leslie A. Geddes Endowment at Purdue University (to C. J. Goergen). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or NSF.
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Consolini, J., Oberman, A.G., Sayut, J. et al. Investigation of direction- and age-dependent prestretch in mouse cranial dura mater. Biomech Model Mechanobiol (2024). https://doi.org/10.1007/s10237-023-01802-6
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DOI: https://doi.org/10.1007/s10237-023-01802-6