Computational modelling of fluid and solute transport in the brain

Martinac, Adam D.; Bilston, Lynne E.

doi:10.1007/s10237-019-01253-y

Review Paper
Published: 13 November 2019

Computational modelling of fluid and solute transport in the brain

Adam D. Martinac¹ &
Lynne E. Bilston¹

Biomechanics and Modeling in Mechanobiology volume 19, pages 781–800 (2020)Cite this article

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Abstract

The glymphatic system is proposed to be a unidirectional fluid and solute circulation pathway in the brain involving transport through perivascular spaces, brain interstitium and glial cells. Some aspects of the glymphatic hypothesis are controversial, particularly the outflow pathway, and little is known about the forces that govern such fluid transport at each stage. Computational and mathematical modelling approaches can be valuable for testing hypotheses and are a useful adjunct to experimental research in this field. This article presents an overview of computational modelling studies associated with glymphatic fluid transport in the brain, from fluid inflow, transparenchymal transport and outflow. A broad range of modelling approaches have been used to investigate fluid and solute transport from purely analytical models to hydraulic resistance networks and computational fluid dynamics models. Most of the modelling attention has focused on periarterial inflow and transport through the parenchyma. Collectively these studies suggest that arterial pulsation is unlikely to be the sole inflow driving force, and diffusion is most likely the dominant mode of transport in the parenchymal extracellular spaces. Models of efflux are limited and have not been able to shed light on the driving forces for fluid outflow from the central nervous system.

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Funding

ADM is supported by an Australian Government Research Training Program Scholarship and a UNSW Prince of Wales Clinical School Scholarship. LEB is supported by an NHMRC senior research fellowship.

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Neuroscience Research Australia and Prince of Wales Clinical School, UNSW, Kensington, Australia
Adam D. Martinac & Lynne E. Bilston

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Adam D. Martinac
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Lynne E. Bilston
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Correspondence to Lynne E. Bilston.

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Martinac, A.D., Bilston, L.E. Computational modelling of fluid and solute transport in the brain. Biomech Model Mechanobiol 19, 781–800 (2020). https://doi.org/10.1007/s10237-019-01253-y

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Received: 20 June 2019
Accepted: 05 November 2019
Published: 13 November 2019
Issue Date: June 2020
DOI: https://doi.org/10.1007/s10237-019-01253-y

Keywords

Simulation
Brain waste clearance
Glymphatic