Abstract
The dissipative particle dynamics (DPD) technique is employed to model the trajectories of micro-objects in a practical microfluidic device. The simulation approach is first developed using an in-house Fortran code to model Stokes flow at Reynolds number of 0.01. The extremely low Reynolds number is achieved by adjusting the DPD parameters, such as force coefficients, thermal energies of the particles, and time steps. After matching the numerical flow profile with the analytical results, the technique is developed further to simulate the deflection of micro-objects under the effect of a deflecting external force in a rectangular microchannel. A mapping algorithm is introduced to establish the scaling relationship for the deflecting force between the physical device and the DPD domain. Dielectrophoresis is studied as a case study for the deflecting force, and the trajectory of a single red blood cell under the influence of the dielectrophoretic force is simulated. The device is fabricated using standard microfabrication techniques, and the experiments involving a dilute sample of red blood cells are performed at two different cases of the actuation voltage. Good agreement between the numerical and experimental results is achieved.
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References
Abu-Nada E (2011) Energy conservative dissipative particle dynamics simulation of natural convection in liquids. J Heat Transf 133:112502
Agarwal T, Maiti TK (2019) Dielectrophoresis-based devices for cell patterning. In: Bioelectronics and medical devices. Elsevier, pp 493–511
Alazzam A, Stiharu I, Bhat R, Meguerditchian AN (2011) Interdigitated comb-like electrodes for continuous separation of malignant cells from blood using dielectrophoresis. Electrophoresis 32:1327–1336
Alazzam A, Mathew B, Khashan S (2017a) Microfluidic platforms for bio-applications. In: Zhang D, Wei B (eds) Advanced mechatronics and MEMS devices II. Microsystems and Nanosystems, Springer, Cham
Alazzam A, Mathew B, Alhammadi F (2017b) Novel microfluidic device for the continuous separation of cancer cells using dielectrophoresis. J Sep Sci 40:1193–1200
Berthier J, Silberzan P (2010) Microfluidics for biotechnology. Artech House, Boston
Boek E, Coveney PV, Lekkerkerker H, van der Schoot P (1997) Simulating the rheology of dense colloidal suspensions using dissipative particle dynamics. Phys Rev E 55:3124
Chen S, Doolen GD (1998) Lattice boltzmann method for fluid flows. Annu Rev Fluid Mech 30:329–364
Chen S, Phan-Thien N, Khoo BC, Fan XJ (2006) Flow around spheres by dissipative particle dynamics. Phys Fluids 18:103605
Choi S, Song S, Choi C, Park J-K (2007) Continuous blood cell separation by hydrophoretic filtration. Lab Chip 7:1532–1538
Destgeer G, Sung HJ (2015) Recent advances in microfluidic actuation and micro-object manipulation via surface acoustic waves. Lab Chip 15:2722–2738
Destgeer G, Lee KH, Jung JH, Alazzam A, Sung HJ (2013) Continuous separation of particles in a PDMS microfluidic channel via travelling surface acoustic waves (TSAW). Lab Chip 13:4210–4216
Ermak DL, McCammon J (1978) Brownian dynamics with hydrodynamic interactions. J Chem Phys 69:1352–1360
Espanol P, Warren P (1995) Statistical mechanics of dissipative particle dynamics. EPL (Europhys Lett) 30:191
Fan X, Phan-Thien N, Chen S, Wu X, Yong Ng T (2006) Simulating flow of DNA suspension using dissipative particle dynamics. Phys Fluids 18:063102
Gao C, Zhang P, Marom G, Deng Y, Bluestein D (2017) Reducing the effects of compressibility in DPD-based blood flow simulations through severe stenotic microchannels. J Comput Phys 335:812–827
Groot RD, Warren PB (1997) Dissipative particle dynamics: bridging the gap between atomistic and mesoscopic simulation. J Chem Phys 107:4423–4435
Hartmann D (2010) A multiscale model for red blood cell mechanics. Biomech Model Mechanobiol 9:1–17
Hoogerbrugge P, Koelman J (1992) Simulating microscopic hydrodynamic phenomena with dissipative particle dynamics. EPL (Europhys Lett) 19:155
Iliescu C, Xu G, Tong WH, Yu F, Bălan CM, Tresset G, Yu H (2015) Cell patterning using a dielectrophoretic–hydrodynamic trap. Microfluid Nanofluid 19:363–373
Jerabek-Willemsen M, André T, Wanner R, Roth HM, Duhr S, Baaske P, Breitsprecher D (2014) Microscale thermophoresis: interaction analysis and beyond. J Mol Struct 1077:101–113
Khashan SA, Dagher S, Alazzam A, Mathew B, Hilal-Alnaqbi A (2017) Microdevice for continuous flow magnetic separation for bioengineering applications. J Micromech Microeng 27:055016
Kleinstreuer C, Zhang Z, Li Z, Roberts WL, Rojas C (2008) A new methodology for targeting drug-aerosols in the human respiratory system. Int J Heat Mass Transf 51:5578–5589
Kumar A, Asako Y, Abu-Nada E, Krafczyk M, Faghri M (2009) From dissipative particle dynamics scales to physical scales: a coarse-graining study for water flow in microchannel. Microfluid Nanofluid 7:467
Kurita R, Hayashi K, Fan X, Yamamoto K, Kato T, Niwa O (2002) Microfluidic device integrated with pre-reactor and dual enzyme-modified microelectrodes for monitoring in vivo glucose and lactate. Sens Actuators B Chem 87:296–303
Leong FY, Li Q, Lim CT, Chiam K-H (2011) Modeling cell entry into a micro-channel. Biomech Model Mechanobiol 10:755–766
Liu M, Liu G (2010) Smoothed particle hydrodynamics (SPH): an overview and recent developments. Arch Comput Methods Eng 17:25–76
Liu M, Liu G, Zhou L, Chang J (2015) Dissipative particle dynamics (dpd): an overview and recent developments. Arch Comput Methods Eng 22:529–556
Mai-Duy N, Pan D, Phan-Thien N, Khoo B (2013) Dissipative particle dynamics modeling of low Reynolds number incompressible flows. J Rheol 57:585–604
Marsh C, Backx G, Ernst M (1997) Static and dynamic properties of dissipative particle dynamics. Phys Rev E 56:1676
Meakin P, Xu Z (2009) Dissipative particle dynamics and other particle methods for multiphase fluid flow in fractured and porous media. Progr Comput Fluid Dyn Int J 9:399–408
Neethirajan S, Kobayashi I, Nakajima M, Wu D, Nandagopal S, Lin F (2011) Microfluidics for food, agriculture and biosystems industries. Lab Chip 11:1574–1586
Nerguizian V, Stiharu I, Al-Azzam N, Yassine-Diab B, Alazzam A (2019) The effect of dielectrophoresis on living cells: crossover frequencies and deregulation in gene expression. Analyst 144:3853–3860. https://doi.org/10.1039/C9AN00320G
Ng K, Sheu T (2017) Refined energy-conserving dissipative particle dynamics model with temperature-dependent properties and its application in solidification problem. Phys Rev E 96:043302
Phan-Thien N, Mai-Duy N, Khoo B (2014) A spring model for suspended particles in dissipative particle dynamics. J Rheol 58:839–867
Pivkin IV, Karniadakis GE (2005) A new method to impose no-slip boundary conditions in dissipative particle dynamics. J Comput Phys 207:114–128
Pohl HA (1951) The motion and precipitation of suspensoids in divergent electric fields. J Appl Phys 22:869–871
Pol R, Céspedes F, Gabriel D, Baeza M (2017) Microfluidic lab-on-a-chip platforms for environmental monitoring. TrAC Trends Anal Chem 95:62–68
Qian C, Huang H, Chen L, Li X, Ge Z, Chen T, Yang Z, Sun L (2014) Dielectrophoresis for bioparticle manipulation. Int J Mol Sci 15:18281–18309
Revenga M, Zuniga I, Espanol P (1999) Boundary conditions in dissipative particle dynamics. Comput Phys Commun 121:309–311
Rothman DH, Zaleski S (2004) Lattice-gas cellular automata: simple models of complex hydrodynamics, vol 5. Cambridge University Press, Cambridge
Sackmann EK, Fulton AL, Beebe DJ (2014) The present and future role of microfluidics in biomedical research. Nature 507:181
Steiner T, Cupelli C, Zengerle R, Santer M (2009) Simulation of advanced microfluidic systems with dissipative particle dynamics. Microfluid Nanofluid 7:307–323
Waheed W, Alazzam A, Mathew B, Christoforou N, Abu-Nada E (2018a) Lateral fluid flow fractionation using dielectrophoresis (LFFF-DEP) for size-independent, label-free isolation of circulating tumor cells. J Chromatogr B 1087:133–137
Waheed W, Alazzam A, Abu-Nada E, Khashan S, Abutayeh M (2018b) A microfluidics device for 3d switching of microparticles using dielectrophoresis. J Electrostat 94:1–7
Waheed W, Alazzam A, Mathew B, Abu-Nada E, Al-Khateeb AN (2018c) In: A scalabale microfluidic device for switching of microparticles using dielectrophoresis, ASME 2018 international mechanical engineering congress and exposition. American Society of Mechanical Engineers, pp V010T013A014–V010T013A014
Waheed W, Alazzam A, Al-Khateeb AN, Sung HJ, Abu-Nada E (2019) Investigation of DPD transport properties in modeling bioparticle motion under the effect of external forces: low Reynolds number and high Schmidt scenarios. J Chem Phys 150:054901
Wang L, Flanagan LA, Jeon NL, Monuki E, Lee AP (2007) Dielectrophoresis switching with vertical sidewall electrodes for microfluidic flow cytometry. Lab Chip 7:1114–1120
Willemsen S, Hoefsloot H, Iedema P (2000) No-slip boundary condition in dissipative particle dynamics. Int J Mod Phys C 11:881–890
Wu L, Lanry Yung L-Y, Lim K-M (2012) Dielectrophoretic capture voltage spectrum for measurement of dielectric properties and separation of cancer cells. Biomicrofluidics 6:014113
Xiao L, Liu Y, Chen S, Fu B (2016) Numerical simulation of a single cell passing through a narrow slit. Biomech Model Mechanobiol 15:1655–1667
Xiong W, Zhang J (2012) Two-dimensional lattice boltzmann study of red blood cell motion through microvascular bifurcation: cell deformability and suspending viscosity effects. Biomech Model Mechanobiol 11:575–583
Xu Z, Kleinstreuer C (2018) Direct nanodrug delivery for tumor targeting subject to shear-augmented diffusion in blood flow. Med Biol Eng Comput 56(15):1–10
Ye T, Phan-Thien N, Khoo BC, Lim CT (2014) Dissipative particle dynamics simulations of deformation and aggregation of healthy and diseased red blood cells in a tube flow. Phys Fluids 26:111902
Ye T, Phan-Thien N, Lim CT (2016) Particle-based simulations of red blood cells—a review. J Biomech 49:2255–2266
Acknowledgements
This publication is based upon work supported by the Khalifa University of Science and Technology under Award No. [CIRA-2019-014]
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Waheed, W., Alazzam, A., Al-Khateeb, A.N. et al. Dissipative particle dynamics for modeling micro-objects in microfluidics: application to dielectrophoresis. Biomech Model Mechanobiol 19, 389–400 (2020). https://doi.org/10.1007/s10237-019-01216-3
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DOI: https://doi.org/10.1007/s10237-019-01216-3