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Mechanical behavior of abdominal aorta aneurysm in rat model treated by cell therapy using mesenchymal stem cells

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Abstract

Regenerative medicine to substitute conventional surgery or an endovascular stent constitutes currently a challenge to treat abdominal aneurysm artery (AAA). The present paper addresses the following question: Can a cellular therapy from mesenchymal stem cells reestablish the mechanical properties of damaged abdominal aorta? For that, the xenograft rat model that mimics arterial dilatation due to aneurysmal disease is used to study the effects of the proposed cellular therapy. To investigate the changes in the mechanical behavior of the arterial wall, the artery is assumed to be made of a hyperelastic and incompressible material characterized by a strain energy function fitted to the average data set of uniaxial tests of AAA tissue samples. In order to compute the stresses in the artery by using an analytical approach, the aneurysm is represented as a “parabolic-exponential” thin membrane. Thus, when compared to healthy, untreated and treated arteries, the obtained results demonstrate that the cellular therapy stabilizes the geometry of AAAs, improves the stiffness of the tissue and decreases stress variations in the arterial wall.

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Acknowledgments

This work is supported by CNRS, University Paris-Est Creteil and the European Union Grant (FP7-Health-200647, Fighting Aneurysmal Diseases). We would like to acknowledge C. Justine, J. Dai, F. Mohand-Kaci (University Paris-Est Creteil, France) and N. Assoul (INSERM, U698) for their help in the experimental protocols.

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Authors and Affiliations

  1. CNRS EAC 4396, Université Paris-Est Créteil, Faculté de Médecine - Centre de Recherches Chirurgicales, 8 rue du Général, Sarrail, 94010 , Créteil, France

    Mustapha Zidi & Eric Allaire

  2. Department of Vascular Surgery, Henri Mondor Hospital AP-HP, 94010 , Créteil, France

    Eric Allaire

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  1. Mustapha Zidi
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  2. Eric Allaire
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Correspondence to Mustapha Zidi.

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Zidi, M., Allaire, E. Mechanical behavior of abdominal aorta aneurysm in rat model treated by cell therapy using mesenchymal stem cells. Biomech Model Mechanobiol 14, 185–194 (2015). https://doi.org/10.1007/s10237-014-0586-4

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  • DOI: https://doi.org/10.1007/s10237-014-0586-4

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