Skip to main content
Log in

Theoretical and experimental study of growth and remodeling in the developing heart

  • Original paper
  • Published:
Biomechanics and Modeling in Mechanobiology Aims and scope Submit manuscript

Abstract

A theoretical model is presented for growth and remodeling in the developing embryonic heart. The model is a thick-walled tube composed of two layers of orthotropic pseudoelastic material. The analysis includes stress and strain dependent volumetric growth, with changes in material properties specified to reflect the evolving structure of the heart wall. For use in model validation, experimental measurements of ventricular opening angles are reported for 3–4-day old chick embryos under control and pressure overload conditions. Owing to changes in residual stress in the overloaded heart, the opening angle decreased from 31 ± 10° to −8 ± 12° (mean ± SD) within 12 h and then increased slightly. The opening angle at 12 h was significantly less than the control value. With an appropriate choice of parameters, the model yields reasonable agreement with these and other published opening angle data, as well as with temporal changes in lumen radius, wall thickness, epicardial strains, and pressure–volume curves during development before and after birth.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received: 26 November 2001 / Accepted: 21 December 2001

Rights and permissions

Reprints and permissions

About this article

Cite this article

Taber, L., Chabert, S. Theoretical and experimental study of growth and remodeling in the developing heart. Biomechan Model Mechanobiol 1, 29–43 (2002). https://doi.org/10.1007/s10237-002-0002-3

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10237-002-0002-3

Keywords

Navigation