The impact of the gustiness on surface waves under storm conditions is investigated with focus on the appearance of wave groups with extreme high amplitude and wavelength in the North Sea. During many storms characterized by extremely high individual waves measured near the German coast, especially in cold air outbreaks, the moving atmospheric open cells are observed by optical and radar satellites. According to measurements, the footprint of the cell produces a local increase in the wind field at sea surface, moving as a consistent system with a propagation speed near to swell wave-traveling speed. The optical and microwave satellite data are used to connect mesoscale atmospheric turbulences and the extreme waves measured. The parameters of open cells observed are used for numerical spectral wave modeling. The North Sea with horizontal resolution of 2.5 km and with focus on the German Bight was simulated. The wind field “storm in storm,” including moving organized mesoscale eddies with increased wind speed, was generated. To take into account the rapid moving gust structure, the input wind field was updated each 5 min. The test cases idealized with one, two, and four open individual cells and, respectively, with groups of open cells, with and without preexisting sea state, as well the real storm conditions, are simulated. The model results confirm that an individual-moving open cell can cause the local significant wave height increase in order of meters within the cell area and especially in a narrow area of 1–2 km at the footprint center of a cell (the cell's diameter is 40–90 km). In a case of a traveling individual open cell with 15 m·s−1 over a sea surface with a preexisting wind sea of and swell, a local significant wave height increase of 3.5 m is produced. A group of cells for a real storm condition produces a local increase of significant wave height of more than 6 m during a short time window of 10–20 min (cell passing). The sea surface simulation from modeled wave spectra points out the appearance of wave groups including extreme individual waves with a period of about 25 s and a wavelength of more than 350 m under the cell's footprint. This corresponds well with measurement of a rogue wave group with length of about 400 m and a period of near 25 s. This has been registered at FiNO-1 research platform in the North Sea during Britta storm on November 1, 2006 at 04:00 UTC. The results can explain the appearance of rogue waves in the German Bight and can be used for ship safety and coastal protection. Presently, the considered mesoscale gustiness cannot be incorporated in present operational wave forecasting systems, since it needs an update of the wind field at spatial and temporal scales, which is still not available for such applications. However, the scenario simulations for cell structures with appropriate travel speed, observed by optical and radar satellites, can be done and applied for warning messages.