Unilateral Basal Cell Carcinomas: An Unusual Entity Treated with Photodynamic Therapy

  • Joshua E. LaneEmail author
  • Jennifer H. Allen
  • Tanda N. Lane
  • Jack L. LesherJr



Unilateral localized basal cell carcinomas are an uncommon finding that presents both a diagnostic and therapeutic challenge. Exclusion of unilateral nevoid basal cell carcinoma syndrome is indicated. There are few reports in the literature regarding this entity and even less regarding therapeutic strategies.


We present a patient with unilateral localized basal cell carcinomas who was successfully treated with photodynamic therapy.


Photodynamic therapy was started using Levulan® Kerastick® as previously described. The topical solution was applied to the patient’s back and illuminated the following day via the BLU-U Blue Light Illuminator.


The patient tolerated the procedure well and without complications. The patient had an excellent therapeutic response with no clinically apparent basal cell carcinomas for 18 months.


We report a patient with unilateral basal cell carcinomas successfully treated with photodynamic therapy. This uncommon entity represents a diagnostic challenge in its inherent absence of the classic clinical and radiographic findings of nevoid basal cell carcinoma syndrome. Like nevoid basal cell carcinoma syndrome, unilateral basal cell carcinomas poses a therapeutic challenge with the sheer number of cutaneous tumors. The use of photodynamic therapy carries a proven therapeutic efficacy, a low rate of adverse events and excellent cosmesis.


Photodynamic Therapy Basal Cell Carcinoma Nevoid Basal Cell Carcinoma Syndrome Topical Imiquimod Superficial Basal Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Le carcinome basocellulaire métastatique unilatéral localisé est rare et constitue un défi tant au niveau du diagnostic que du traitement. L’exclusion de la naevomatose basocellulaire est indiquée. Peu de rapports publiés traitent de cette entité ou des stratégies thérapeutiques.


Nous présentons le cas d’un patient atteint de carcinomes basocellulaires unilatéraux localisés qui a bien réagi à la thérapie photodynamique (TPD).


La thérapie photodynamique a été entamée au moyen de Levulan® Kerastick®. La solution topique a été enduite sur le dos du patient et illuminée, le lendemain, par le BLU-U Blue Light Illuminator.


Le patient a bien toléré la procédure et aucune complication ne s’en est suivie. Le patient a bien réagi au traitement et a été libre de carcinomes cellulaires apparents pendant 18 mois.


Nous rapportons le cas d’un patient présentant des carcinomes basocellulaires unilatéraux localisés qui ont été traités au moyen de la TPD. Le diagnostic de cette entité rare est difficile en raison de l’absence dans les tests cliniques et radiologiques du syndrome de la naevomatose basocellulaire. Tout comme la naevomatose basocellulaire, le carcinome basocellulaire unilatéral pose un défi au niveau de la thérapie vu le seul nombre de tumeurs cutanées. Le recours à la thérapie photodynamique s’est avéré efficace, avec un faible taux d’événements indésirables et un bon résultat cosmétique.



We would like to acknowledge Brian C. Brockway, M.S. of the Department of Medical Photography and Illustration at the Veteran’s Affairs Medical Center in Augusta, Georgia for illustrations.


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Joshua E. Lane
    • 1
    • 4
    Email author
  • Jennifer H. Allen
    • 2
  • Tanda N. Lane
    • 3
  • Jack L. LesherJr
    • 1
  1. 1.Section of Dermatology, Department of MedicineThe Medical College of GeorgiaAugustaUSA
  2. 2.Allen Dermatology & Skin Cancer CenterMaconUSA
  3. 3.Department of DermatologyEmory University School of MedicineAtlantaUSA
  4. 4.Joshua E. LaneMaconUSA

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