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Facial Lipoatrophy Following Systemic Lupus Erythematosus

Abstract

Background: Acquired partial lipodystrophy is a rare disorder. An association with systemic lupus erythematosus has been reported. In these cases, an immunologic basis is suggested by the presence of C3 nephritic factor and hypocomplementemia. Objective: The following report presents the case of a woman who developed a rapid loss of facial subcutaneous fat a few months after complete spontaneous resolution of cutaneous lesions of lupus. Conclusion: Absence of C3NeF in this case suggests that other immunological factors may be involved in the pathogenesis.

Antécédents: La lipodystrophie partielle acquise est un trouble rare. Une association avec le lupus érythémateux systémique a été rapportée. Dans ces cas, on suggère une cause immunologique, étayée par la présence du facteur C3 néphritique (C3NF) et une hypocomplémentémie. Objectifs: Le présent rapport expose le cas d’une femme ayant subi une perte rapide du tissu adipeux sous-cutané quelques mois suivant la résorption spontanée de lésions cutanées dues au lupus. Conclusion: Dans ce cas, l’absence du C3NF suggère que d’autres facteurs immunologiques peuvent être impliqués dans la pathogenèse.

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Correspondence to Yves Poulin.

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Dupéré, A., Poulin, Y. Facial Lipoatrophy Following Systemic Lupus Erythematosus . JCMS 7, 232–235 (2003). https://doi.org/10.1007/s10227-002-0159-5

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