The European Journal of Health Economics

, Volume 12, Issue 3, pp 219–230 | Cite as

Utilities and disutilities for attributes of injectable treatments for type 2 diabetes

  • Kristina S. Boye
  • Louis S. MatzaEmail author
  • Kimberly N. Walter
  • Kate Van Brunt
  • Andrew C. Palsgrove
  • Aodan Tynan
Original Paper



Although cost-utility models are frequently used to estimate treatment outcomes for type 2 diabetes, utilities are not available for key attributes of injectable treatments. The purpose of this study was to identify the utility or disutility of three injection-related attributes (dose frequency, dose flexibility, injection site reaction) that may influence patient preference.


Patients with type 2 diabetes in Scotland completed standard gamble (SG) interviews to assess the utility of hypothetical health states and their own current health state. The EQ-5D, PGWB, IWQOL-Lite, and QIDS were also administered. Construct validity and differences among health states were examined.


A total of 151 patients completed interviews. Of the three injection-related attributes, dose frequency was the only attribute with a statistically significant impact on utility (in a multiple regression model, p = 0.01). Weekly injections were associated with an average added utility of 0.023 in comparison to everyday injections. Flexible dosing and injection site reactions resulted in somewhat smaller utility shifts that were in the expected directions (+0.006 and −0.011, respectively). SG utility of current health (mean = 0.897) demonstrated construct validity through statistically significant correlations with patient-reported outcome measures.


The three injection attributes were associated with small utility shifts in the expected directions. Dose frequency appears to be the most important of the three attributes from the patients’ perspective. The vignette-based SG approach was feasible and useful for assessing added utility or disutility of injection-related attributes associated with treatments for type 2 diabetes.


Utilities Type 2 diabetes Injection Dose frequency Patient preference Standard gamble 

JEL Classification

I00 I10 I19 



The authors would like to thank Ray Hsieh for statistical programming; Julie Meilak for production assistance; Anne Brooks and Thomas Albert for assistance with participant recruitment and data collection; Terri Kim, Robert Brodows, and Dennis Revicki for expert consultation. Permission to use all patient-reported outcome measures was granted by the instrument developers. Funding for the study was provided by Eli Lilly and Company. Publication of this study was not dependent on the results.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Kristina S. Boye
    • 1
  • Louis S. Matza
    • 2
    Email author
  • Kimberly N. Walter
    • 2
  • Kate Van Brunt
    • 2
  • Andrew C. Palsgrove
    • 2
  • Aodan Tynan
    • 1
  1. 1.Eli Lilly and CompanyIndianapolisUSA
  2. 2.Center for Health Outcomes ResearchUnited BioSource CorporationBethesdaUSA

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