Transcranial magnetic stimulation for migraine: clinical effects

Abstract

The objective was to assess the impact of transcranial magnetic stimulation (TMS) on pain and the autonomic nervous system (ANS) in migraine. Fortytwo people [mean age 41.43±11.69 (SD) years, 36 females] were randomised into high vs. low TMS stimulation groups and received 2 brief pulses of TMS. Thirty-three (33/42) individuals had heart-rate variability assessed, before and after stimulation. No group effects were found. Pain decreased by 75%; 32% of people after 1 treatment reported no headache after 24 h. Mean heart rate decreased from 79.05±10.27 to 72.89±11.35 beats/min. The low-frequency (LF) and the high-frequency (HF) areas derived from power spectral analyses increased [mean 6522±1277 to 8315±1009 beats/min2 (LF) (p=0.001) and mean 5600±1568 to 8755±3071 beats/min2 (HF) (p=0.001)]. The LF:HF ratio decreased from mean 1.31±0.51 to 1.13±0.48 (NS). TMS produces immediate, sustained reductions in pain and modification of the ANS.

Author information

Affiliations

Authors

Corresponding author

Correspondence to B. M. Clarke.

Rights and permissions

This article is published under an open access license. Please check the 'Copyright Information' section for details of this license and what re-use is permitted. If your intended use exceeds what is permitted by the license or if you are unable to locate the licence and re-use information, please contact the Rights and Permissions team.

About this article

Cite this article

Clarke, B.M., Upton, A.R.M., Kamath, M.V. et al. Transcranial magnetic stimulation for migraine: clinical effects. J Headache Pain 7, 341–346 (2006). https://doi.org/10.1007/s10194-006-0329-8

Download citation

Key words

  • Migraine
  • Transcranial magnetic stimulation
  • Pain