Advertisement

The Journal of Headache and Pain

, Volume 7, Issue 5, pp 341–346 | Cite as

Transcranial magnetic stimulation for migraine: clinical effects

  • B. M. ClarkeEmail author
  • A. R. M. Upton
  • M. V. Kamath
  • T. Al-Harbi
  • C. M. Castellanos
Open Access
Original

Abstract

The objective was to assess the impact of transcranial magnetic stimulation (TMS) on pain and the autonomic nervous system (ANS) in migraine. Fortytwo people [mean age 41.43±11.69 (SD) years, 36 females] were randomised into high vs. low TMS stimulation groups and received 2 brief pulses of TMS. Thirty-three (33/42) individuals had heart-rate variability assessed, before and after stimulation. No group effects were found. Pain decreased by 75%; 32% of people after 1 treatment reported no headache after 24 h. Mean heart rate decreased from 79.05±10.27 to 72.89±11.35 beats/min. The low-frequency (LF) and the high-frequency (HF) areas derived from power spectral analyses increased [mean 6522±1277 to 8315±1009 beats/min2 (LF) (p=0.001) and mean 5600±1568 to 8755±3071 beats/min2 (HF) (p=0.001)]. The LF:HF ratio decreased from mean 1.31±0.51 to 1.13±0.48 (NS). TMS produces immediate, sustained reductions in pain and modification of the ANS.

Key words

Migraine Transcranial magnetic stimulation Pain 

Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • B. M. Clarke
    • 1
    • 2
    Email author
  • A. R. M. Upton
    • 1
  • M. V. Kamath
    • 1
  • T. Al-Harbi
    • 1
  • C. M. Castellanos
    • 1
  1. 1.Division of NeurologyMcMaster UniversityHamiltonCanada
  2. 2.Hamilton Health Sciences Centre, Room 4U6Department of Clinical Neurology McMaster UniversityHamiltonCanada L8N 3Z5

Personalised recommendations