Skip to main content
Log in

Traitement endoscopique des varices gastriques

Endoscopic treatment of gastric varices

  • Mise au Point / Update
  • Published:
Acta Endoscopica

Résumé

Le saignement par rupture de varice gastrique est un événement rare et grave, sa prise en charge doit être multidisciplinaire et implique une bonne connaissance du réseau vasculaire. Le seul traitement endoscopique reconnu à ce jour et recommandé est l’obturation par cyanoacrylate. Ce traitement efficace est tout de même imparfait avec 5 à 10 % de récidives et des complications graves, voire fatales. De nouvelles modalités thérapeutiques comme l’échoendoscopie thérapeutique vasculaire sont venues enrichir l’arsenal thérapeutique avec l’injection de coils et ou de cyanoacrylate dans les perforantes ou dans les varices gastriques avec de très bons résultats. Faute d’études randomisées, ce type de traitement n’apparaît pas encore dans les recommandations. Seul l’avenir prouvera que les nouveaux traitements endoscopiques ne sont pas que de la poudre aux yeux. Les radiologues ne sont jamais très loin des endoscopistes et heureusement car le transjugular intrahepatic portosystemic shunt (TIPS) est une alternative de premier choix au traitement endoscopique qui doit toujours être envisagée, surtout chez les patients à risque.

Abstract

Gastric variceal bleeding is a challenge with worst outcomes than oesphageal variceal. The management needs pluridisciplinary discussions and correct appreciation of vascular portal hypertension shunts. Current guidelines recommend endoscopic therapy as first-line with cyanoacrylate obturation. This effective therapy is not perfect with up to 5 to 10% of rebleeding and serious complications. Recent therapies as ultrasound vascular interventional endoscopy with coils or cyano-acrylate guided injection appears as a really promising weapon. Without randomized and controlled studies, this endoscopic technic can’t appear in current guidelines. Future will show that recent endoscopic therapies are not just smokescreen. Interventional radiologists have come to the rescue of many endoscopists when managing bleeding varices. Transjugular intrahepatic portosystemic shunt is indeed effective in the prevention of gastric variceal rebleeding especially for high risk patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Références

  1. Sarin SK, Lahoti D, Saxena SP, Murthy NS, Makwana UK. Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients. Hepatology 1992;16:1343–1349.

    Article  CAS  PubMed  Google Scholar 

  2. Kim T, Shijo H, Kokawa H, Tokumitsu H, Kubara K, Ota K, et al. Risk factors for hemorrhage from gastric fundal varices. Hepatology 1997;25:307–312.

    Article  CAS  PubMed  Google Scholar 

  3. de Franchis R. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol 2014;53:762–768.

    Article  Google Scholar 

  4. Soehendra N, Nam VC, Grimm H, Kempeneers I. Endoscopic obliteration of large esophagogastric varices with bucrylate. Endoscopy 1986;18:25–26.

    Article  CAS  PubMed  Google Scholar 

  5. Sarin SK, Jain AK, Jain M, Gupta R. A randomized controlled trial of cyanoacrylate versus alcohol injection in patients with isolated fundic varices. Am J Gastroenterol 2002;97:1010–1015.

    Article  CAS  PubMed  Google Scholar 

  6. Lo GH, Lai KH, Cheng JS, Chen MH, Chiang HT. A prospective, randomized trial of butyl cyanoacrylate injection versus band ligation in the management of bleeding gastric varices. Hepatology 2001;33:1060–1064.

    Article  CAS  PubMed  Google Scholar 

  7. Tan PC, Hou MC, Lin HC, Liu TT, Lee FY, Chang FY, et al. A randomized trial of endoscopic treatment of acute gastric variceal hemorrhage: N-butyl-2-cyanoacrylate injection versus band ligation. Hepatology 2006;43:690–697.

    Article  PubMed  Google Scholar 

  8. Caldwell S. Gastric varices: is there a role for endoscopic cyanoacrylates, or are we entering the BRTO era? Am J Gastroenterol 2012;107:1784–1790.

    Article  PubMed  Google Scholar 

  9. Procaccini NJ, Al-Osaimi AM, Northup P, Argo C, Caldwell SH. Endoscopic cyanoacrylate versus transjugular intrahepatic portosystemic shunt for gastric variceal bleeding: a single-center U.S. analysis. Gastrointest Endosc 2009;70:881–887.

    Article  PubMed  Google Scholar 

  10. Caldwell SH, Hespenheide EE, Greenwald BD, Northup PG, Patrie JT. Enbucrilate for gastric varices: extended experience in 92 patients. Aliment Pharmacol Ther 2007;26:49–59.

    Article  CAS  PubMed  Google Scholar 

  11. Cheng PN, Sheu BS, Chen CY, Chang TT, Lin XZ. Splenic infarction after histoacryl injection for bleeding gastric varices. Gastrointest Endosc 1998;48:426–427.

    Article  CAS  PubMed  Google Scholar 

  12. Liu CH, Tsai FC, Liang PC, Lee CZ, Yang PM. Splenic vein thrombosis and Klebsiella pneumoniae septicemia after endoscopic gastric variceal obturation therapy with N-butyl-2-cyanoacrylate. Gastrointest Endosc 2006;63:336–338.

    Article  PubMed  Google Scholar 

  13. Lee GH, Kim JH, Lee KJ, Yoo BM, Hahm KB, Cho SW, et al. Life-threatening intraabdominal arterial embolization after histoacryl injection for bleeding gastric ulcer. Endoscopy 2000;32:422–424.

    Article  CAS  PubMed  Google Scholar 

  14. Romero-Castro R, Pellicer-Bautista FJ, Jimenez-Saenz M, Marcos-Sanchez F, Caunedo-Alvarez A, Ortiz-Moyano C, et al. EUS-guided injection of cyanoacrylate in perforating feeding veins in gastric varices: results in 5 cases. Gastrointest Endosc 2007;66:402–407.

    Article  PubMed  Google Scholar 

  15. Gonzalez JM, Giacino C, Pioche M, Vanbiervliet G, Brardjanian S, Ah-Soune P, et al. Endoscopic ultrasound-guided vascular therapy: is it safe and effective? Endoscopy 2012;44:539–542.

    Article  PubMed  Google Scholar 

  16. Levy MJ, Wong Kee Song LM, Kendrick ML, Misra S, Gostout CJ. EUS-guided coil embolization for refractory ectopic variceal bleeding (with videos). Gastrointest Endosc 2008;67:572–574.

    Article  PubMed  Google Scholar 

  17. Romero-Castro R, Pellicer-Bautista F, Giovannini M, Marcos-Sanchez F, Caparros-Escudero C, Jimenez-Saenz M, et al. Endoscopic ultrasound (EUS)-guided coil embolization therapy in gastric varices. Endoscopy 2010;42Suppl 2:E35–E36.

    Article  PubMed  Google Scholar 

  18. Binmoeller KF, Weilert F, Shah JN, Kim J. EUS-guided transesophageal treatment of gastric fundal varices with combined coiling and cyanoacrylate glue injection (with videos). Gastrointest Endosc 2011;74:1019–1025.

    Article  PubMed  Google Scholar 

  19. Romero-Castro R, Ellrichmann M, Ortiz-Moyano C, Subtil-Inigo JC, Junquera-Florez F, Gornals JB, et al. EUS-guided coil versus cyanoacrylate therapy for the treatment of gastric varices: a multicenter study (with videos). Gastrointest Endosc 2013;78:711–721.

    Article  PubMed  Google Scholar 

  20. Sung JJ, Luo D, Wu JC, Ching JY, Chan FK, Lau JY, et al. Early clinical experience of the safety and effectiveness of Hemospray in achieving hemostasis in patients with acute peptic ulcer bleeding. Endoscopy 2011;43:291–295.

    Article  CAS  PubMed  Google Scholar 

  21. Chen YI, Barkun AN, Soulellis C, Mayrand S, Ghali P. Use of the endoscopically applied hemostatic powder TC-325 in cancerrelated upper GI hemorrhage: preliminary experience (with video). Gastrointest Endosc 2012;75:1278–1281.

    Article  PubMed  Google Scholar 

  22. Ibrahim M, El-Mikkawy A, Mostafa I, Deviere J. Endoscopic treatment of acute variceal hemorrhage by using hemostatic powder TC-325: a prospective pilot study. Gastrointest Endosc 2013;78:769–773.

    Article  PubMed  Google Scholar 

  23. Stanley AJ, Smith LA, Morris AJ. Use of hemostatic powder (Hemospray) in the management of refractory gastric variceal hemorrhage. Endoscopy 2013;45Suppl 2 UCTN:E86–E87.

    PubMed  Google Scholar 

  24. Ramesh J, Limdi JK, Sharma V, Makin AJ. The use of thrombin injections in the management of bleeding gastric varices: a singlecenter experience. Gastrointest Endosc 2008;68:877–882.

    Article  PubMed  Google Scholar 

  25. Datta D, Vlavianos P, Alisa A, Westaby D. Use of fibrin glue (beriplast) in the management of bleeding gastric varices. Endoscopy 2003;35:675–678.

    Article  CAS  PubMed  Google Scholar 

  26. Heneghan MA, Byrne A, Harrison PM. An open pilot study of the effects of a human fibrin glue for endoscopic treatment of patients with acute bleeding from gastric varices. Gastrointest Endosc 2002;56:422–426.

    Article  PubMed  Google Scholar 

  27. Barange K, Peron JM, Imani K, Otal P, Payen JL, Rousseau H, et al. Transjugular intrahepatic portosystemic shunt in the treatment of refractory bleeding from ruptured gastric varices. Hepatology 1999;30:1139–1143.

    Article  CAS  PubMed  Google Scholar 

  28. Tripathi D, Helmy A, Macbeth K, Balata S, Lui HF, Stanley AJ, et al. Ten years’ follow-up of 472 patients following transjugular intrahepatic portosystemic stent-shunt insertion at a single centre. Eur J Gastroenterol Hepatol 2004;16:9–18.

    Article  PubMed  Google Scholar 

  29. Lo GH, Liang HL, Chen WC, Chen MH, Lai KH, Hsu PI, et al. A prospective, randomized controlled trial of transjugular intrahepatic portosystemic shunt versus cyanoacrylate injection in the prevention of gastric variceal rebleeding. Endoscopy 2007;39:679–685.

    Article  PubMed  Google Scholar 

  30. Mahadeva S, Bellamy MC, Kessel D, Davies MH, Millson CE. Cost-effectiveness of N-butyl-2-cyanoacrylate (histoacryl) glue injections versus transjugular intrahepatic portosystemic shunt in the management of acute gastric variceal bleeding. Am J Gastroenterol 2003;98:2688–2693.

    Article  CAS  PubMed  Google Scholar 

  31. Garcia-Pagan JC, Caca K, Bureau C, Laleman W, Appenrodt B, Luca A, et al. Early use of TIPS in patients with cirrhosis and variceal bleeding. N Engl J Med 2010;362:2370–2379.

    Article  CAS  PubMed  Google Scholar 

  32. Garcia-Pagan JC, Di Pascoli M, Caca K, Laleman W, Bureau C, Appenrodt B, et al. Use of early-TIPS for high-risk variceal bleeding: results of a post-RCT surveillance study. J Hepatol 2013;58:45–50.

    Article  PubMed  Google Scholar 

  33. Kanagawa H, Mima S, Kouyama H, Mizuo H, Iziri M, Tanabe T, et al. [A successfully treated case of fundic varices by retrograde transvenous obliteration with balloon]. Nihon Shokakibyo Gakkai Zasshi 1991;88:1459–1462.

    CAS  PubMed  Google Scholar 

  34. Kanagawa H, Mima S, Kouyama H, Gotoh K, Uchida T, Okuda K. Treatment of gastric fundal varices by balloon-occluded retrograde transvenous obliteration. J Gastroenterol Hepatol 1996;11:51–58.

    Article  CAS  PubMed  Google Scholar 

  35. Akahoshi T, Hashizume M, Tomikawa M, Kawanaka H, Yamaguchi S, Konishi K, et al. Long-term results of balloon-occluded retrograde transvenous obliteration for gastric variceal bleeding and risky gastric varices: a 10-year experience. J Gastroenterol Hepatol 2008;23:1702–1709.

    Article  PubMed  Google Scholar 

  36. Chen S, Li X, Wei B, Tong H, Zhang MG, Huang ZY, et al. Recurrent variceal bleeding and shunt patency: prospective randomized controlled trial of transjugular intrahepatic portosystemic shunt alone or combined with coronary vein embolization. Radiology 2013;268:900–906.

    Article  PubMed  Google Scholar 

  37. Mishra SR, Sharma BC, Kumar A, Sarin SK. Primary prophylaxis of gastric variceal bleeding comparing cyanoacrylate injection and beta-blockers: a randomized controlled trial. J Hepatol 2011;54:1161–1167.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to E. Cesbron-Métivier.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cesbron-Métivier, E. Traitement endoscopique des varices gastriques. Acta Endosc 44, 171–179 (2014). https://doi.org/10.1007/s10190-014-0392-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10190-014-0392-y

Mots clés

Keywords

Navigation