Skip to main content
SpringerLink
Log in

Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis

Modern Rheumatology (2013)Cite this article

Abstract

Objectives

We aimed to identify a serum biomarker for evaluating the disease activity of relapsing polychondritis (RP).

Methods

We measured and compared serum levels of 28 biomarkers potentially associated with this disease, including soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), high-sensitivity C-reactive protein (hs-CRP), and cartilage oligomeric matrix protein (COMP), in 15 RP patients and 16 healthy donors (HDs). We divided the 15 RP patients into active RP (n = 8) and inactive RP (n = 7) groups, depending on the extent of the disease, and compared candidate markers between groups. The localization of membrane-bound TREM-1 in the affected tissue was examined by immunohistochemistry.

Results

Serum levels of sTREM-1, interferon-γ, chemokine (C–C motif) ligand 4, vascular endothelial growth factor, and matrix metalloproteinases-3 were significantly higher in RP patients than HDs. Among these markers, sTREM-1 had the highest sensitivity and specificity (86.7 and 86.7 %, respectively). Furthermore, the serum level of sTREM-1 was significantly higher in active RP patients than inactive RP patients (p = 0.0403), but this was not true for hs-CRP or COMP. TREM-1 was expressed on endothelial cells in RP lesions.

Conclusions

The serum level of sTREM-1 may be a useful marker of disease activity in RP.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. Jaksch-Wartenhorst R. Polychondropathia. Wien Arch Inn Med. 1923;6:100.

    Google Scholar 

  2. Pearson CM, Kline HM, Newcomer VD. Relapsing polychondritis. N Engl J Med. 1960;263:51–8.

    Article  PubMed  CAS  Google Scholar 

  3. Lahmer T, Treiber M, von Werder A, Foerger F, Knopf A, Heemann U, et al. Relapsing polychondritis: an autoimmune disease with many faces. Autoimmun Rev. 2010;9:540–6.

    Article  PubMed  CAS  Google Scholar 

  4. Kemta Lekpa F, Kraus VB, Chevalier X. Biologics in relapsing polychondritis: a literature review. Semin Arthritis Rheum. 2012;41:712–9.

    Google Scholar 

  5. Rapini RP, Warner NB. Relapsing polychondritis. Clin Dermatol. 2006;24:482–5.

    Article  PubMed  Google Scholar 

  6. Foidart JM, Abe S, Martin GR, Zizic TM, Barnett EV, Lawley TJ, et al. Antibodies to type II collagen in relapsing polychondritis. N Engl J Med. 1978;299:1203–7.

    Article  PubMed  CAS  Google Scholar 

  7. Kempta Lekpa F, Piette JC, Bastuji-Garin S, Kraus VB, Stabler TV, Poole AR, et al. Serum cartilage oligomeric matrix protein (COMP) level is a marker of disease activity in relapsing polychondritis. Clin Exp Rheumatol. 2010;28:553–5.

    Google Scholar 

  8. Michet CJ. Diagnostic evaluation of relapsing polychondritis. http://www.uptodate.com/contents/diagnostic-evaluation-of-relapsing-polychondritis.

  9. Terato K, Shimozuru Y, Katayama K, Takemitsu Y, Yamashita I, Miyatsu M, et al. Specificity of antibodies to type II collagen in rheumatoid arthritis. Arthr Rheum. 1990;33:1493–500.

    Article  CAS  Google Scholar 

  10. Kent PD, Michet CJ Jr, Luthra HS. Relapsing polychondritis. Curr Opin Rheumatol. 2004;16:56–61.

    Article  PubMed  Google Scholar 

  11. Gomez-Pina V, Soares-Schanoski A, Rodriguez-Rojas A, Del Fresno C, Garcia F, Vallejo-Cremades MT, et al. Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes. J Immunol. 2007;179:4065–73.

    PubMed  CAS  Google Scholar 

  12. Gibot S, Cravoisy A. Soluble form of the triggering receptor expressed on myeloid cells-1 as a marker of microbial infection. Clin Med Res. 2004;2:181–7.

    Article  PubMed  CAS  Google Scholar 

  13. McAdam LP, O’Hanlan MA, Bluestone R, Pearson CM. Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine (Baltimore). 1976;55:193–215.

    Article  CAS  Google Scholar 

  14. Damiani JM, Levine HL. Relapsing polychondritis—report of ten cases. Laryngoscope. 1979;89:929–46.

    Article  PubMed  CAS  Google Scholar 

  15. Bouchon A, Dietrich J, Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000;164:4991–5.

    PubMed  CAS  Google Scholar 

  16. Chen LC, Laskin JD, Gordon MK, Laskin DL. Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia. Exp Mol Pathol. 2008;84:145–55.

    Article  PubMed  CAS  Google Scholar 

  17. Gibot S, Kolopp-Sarda MN, Bene MC, Cravoisy A, Levy B, Faure GC, et al. Plasma level of a triggering receptor expressed on myeloid cells-1: its diagnostic accuracy in patients with suspected sepsis. Ann Intern Med. 2004;141:9–15.

    PubMed  CAS  Google Scholar 

  18. Gibot S, Cravoisy A, Kolopp-Sarda MN, Bene MC, Faure G, Bollaert PE, et al. Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis. Crit Care Med. 2005;33:792–6.

    Article  PubMed  CAS  Google Scholar 

  19. Routsi C, Giamarellos-Bourboulis EJ, Antonopoulou A, Kollias S, Siasiakou S, Koronaios A, et al. Does soluble triggering receptor expressed on myeloid cells-1 play any role in the pathogenesis of septic shock? Clin Exp Immunol. 2005;142:62–7.

    Article  PubMed  CAS  Google Scholar 

  20. Tzivras M, Koussoulas V, Giamarellos-Bourboulis EJ, Tzivras D, Tsaganos T, Koutoukas P, et al. Role of soluble triggering receptor expressed on myeloid cells in inflammatory bowel disease. World J Gastroenterol. 2006;12:3416–9.

    PubMed  CAS  Google Scholar 

  21. Kuai J, Gregory B, Hill A, Pittman DD, Feldman JL, Brown T, et al. TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines. Rheumatology (Oxford). 2009;48:1352–8.

    Article  CAS  Google Scholar 

  22. Daikeler T, Regenass S, Tyndall A, Gencay MM, Roth M, Christ-Crain M, et al. Increased serum levels of soluble triggering receptor expressed on myeloid cells-1 in antineutrophil cytoplasmic antibody-associated vasculitis. Ann Rheum Dis. 2008;67:723–4.

    Article  PubMed  CAS  Google Scholar 

  23. Michet CJ. Vasculitis and relapsing polychondritis. Rheum Dis Clin North Am. 1990;16:441–4.

    PubMed  CAS  Google Scholar 

  24. Zeuner M, Straub RH, Rauh G, Albert ED, Scholmerich J, Lang B. Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients. J Rheumatol. 1997;24:96–101.

    PubMed  CAS  Google Scholar 

  25. Bleharski JR, Kiessler V, Buonsanti C, Sieling PA, Stenger S, Colonna M, et al. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol. 2003;170:3812–8.

    PubMed  CAS  Google Scholar 

  26. Bouchon A, Facchetti F, Weigand MA, Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature. 2001;410:1103–7.

    Article  PubMed  CAS  Google Scholar 

  27. Murakami Y, Akahoshi T, Aoki N, Toyomoto M, Miyasaka N, Kohsaka H. Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis. Arthr Rheum. 2009;60:1615–23.

    Article  CAS  Google Scholar 

  28. Yamanaka H, Matsuda Y, Tanaka M, Sendo W, Nakajima H, Taniguchi A, et al. Serum matrix metalloproteinase 3 as a predictor of the degree of joint destruction during the six months after measurement, in patients with early rheumatoid arthritis. Arthr Rheum. 2000;43:852–8.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

We would like to thank Katsunori Takahashi, Yasuo Kunitomo, Yuji Sato, Mikako Koike, and Yumiko Hasegawa for their excellent technical help. This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Health, Labour and Welfare, Japan.

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Institute of Medical Science, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 216-8512, Japan

    Tomoo Sato, Yoshihisa Yamano, Yukiko Shimizu, Hitoshi Ando & Kazuo Yudoh

  2. Department of Pathology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo, 060-8638, Japan

    Utano Tomaru

  3. Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 216-8512, Japan

    Takahiro Okazaki, Hiroko Nagafuchi & Shoichi Ozaki

  4. Departments of Immunology and Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 216-8512, Japan

    Jun Shimizu & Noboru Suzuki

  5. Division of Respiratory and Infectious Diseases, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 216-8512, Japan

    Teruomi Miyazawa

  6. Rheumatic Disease Center, Tokyo Medical University Hachioji Medical Center, 1163 Tate-machi, Hachioji, 193-0998, Japan

    Hiroshi Oka

Authors
  1. Tomoo Sato
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yoshihisa Yamano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Utano Tomaru
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yukiko Shimizu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hitoshi Ando
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Takahiro Okazaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hiroko Nagafuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jun Shimizu
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Shoichi Ozaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Teruomi Miyazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Kazuo Yudoh
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Hiroshi Oka
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Noboru Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Noboru Suzuki.

About this article

Cite this article

Sato, T., Yamano, Y., Tomaru, U. et al. Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis. Mod Rheumatol (2013). https://doi.org/10.1007/s10165-013-0833-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s10165-013-0833-z

Keywords

search

Navigation