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Four cases of MPO-ANCA-positive vasculitis with otitis media, and review of the literature

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Modern Rheumatology

Abstract

Otitis media is one of the common organ injuries that appear during the course of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We experienced four patients with myeloperoxidase (MPO)-ANCA-positive AAV with otitis media. All were elderly Japanese women. MPO-ANCA in our patients was reminiscent of microscopic polyangiitis (MPA), although chest computed tomography (CT) scans revealed characteristics of both granulomatosis with polyangiitis (GPA), showing bronchial lesions and nodule formation, and MPA, showing interstitial changes. Whether our cases should be classified as GPA or MPA is a matter of discussion. We detail their profiles, and review previous literature on MPO-ANCA-positive AAV with otitis media.

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Authors and Affiliations

  1. Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, 5-30 Kitatakamatsu-cho, Miyazaki, Miyazaki, 880-8510, Japan

    Nobuyuki Ono, Kyoko Yoshihiro, Daisuke Oryoji, Motohiro Matsuda, Shigehiro Uezono, Yasufumi Kai, Daisuke Himeji & Akira Ueda

  2. Department of Otolaryngology, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan

    Yoshihiro Ueki

  3. Department of Clinical Immunology and Rheumatology/Infectious Disease, Kyushu University Hospital, Fukuoka, Japan

    Hiroaki Niiro

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  1. Nobuyuki Ono
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Correspondence to Nobuyuki Ono.

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Ono, N., Yoshihiro, K., Oryoji, D. et al. Four cases of MPO-ANCA-positive vasculitis with otitis media, and review of the literature. Mod Rheumatol 23, 554–563 (2013). https://doi.org/10.1007/s10165-012-0682-1

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  • DOI: https://doi.org/10.1007/s10165-012-0682-1

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