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Coexistence of polymyositis and familial Mediterranean fever

  • Case Report
  • Published:
Modern Rheumatology

Abstract

Familial Mediterranean fever (FMF) is an autosomal recessive disease affecting populations surrounding the Mediterranean area. In this case report, we report a Japanese female patient with polymyositis (PM) who presented with periodic fever. Genetic analysis revealed that she had compound heterozygous mutations in exon 2 of the MEFV gene (L110P/E148Q/R202Q). Treatment with colchicines (1.0 mg/day) successfully eliminated febrile attack and normalized the elevated levels of neutrophil CD64 expression, leading to the diagnosis of FMF. The association of FMF and PM has not previously been reported, so we discuss this rare association.

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Acknowledgments

This work was supported by a Grant-in-Aid for Research on intractable diseases from the Ministry of Health, Labour and Welfare of Japan, “Study group of national-wide survey for FMF in Japan.”

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Authors and Affiliations

  1. Department of General Internal Medicine and Rheumatology, Clinical Research Center, NHO National Nagasaki Medical Center, Kubara 2-1001-1, Omura, 856-8652, Japan

    Mami Eguchi, Taiichiro Miyashita, Haruka Shirouzu, Saya Sato, Yasumori Izumi, Atsushi Takeoka, Tadayoshi Ohno, Remi Sumiyoshi, Ayako Nishino, Yuka Jiuchi & Kiyoshi Migita

  2. Department of Rheumatology, Sasebo City General Hospital, Sasebo, Japan

    Fumiaki Nonaka & Katsumi Eguchi

  3. Department of Rheumatology, Nagasaki University Hospital, Nagasaki, Japan

    Atsushi Kawakami

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  1. Mami Eguchi
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  2. Taiichiro Miyashita
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  3. Haruka Shirouzu
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  13. Atsushi Kawakami
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  14. Kiyoshi Migita
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Correspondence to Kiyoshi Migita.

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Eguchi, M., Miyashita, T., Shirouzu, H. et al. Coexistence of polymyositis and familial Mediterranean fever. Mod Rheumatol 23, 374–378 (2013). https://doi.org/10.1007/s10165-012-0649-2

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  • DOI: https://doi.org/10.1007/s10165-012-0649-2

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