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Accumulation of mature B cells in the inflamed muscle tissue of a patient with anti-155/140 antibody-positive juvenile dermatomyositis

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Modern Rheumatology

Abstract

We report the first case of a Japanese patient with anti-155/140 antibody-positive juvenile dermatomyositis (JDM). Her clinical features included severe cutaneous involvement. Serum B cell-activating factor levels were significantly increased. Mature class-switched memory B cells accumulated in inflamed muscle tissue but decreased in peripheral blood. These findings indicate that loss of B cell tolerance and accumulation of mature B cells in inflamed muscle tissue play an important role in the pathogenesis of JDM.

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Authors and Affiliations

  1. Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan

    Tadafumi Yokoyama, Masaki Shimizu, Sayaka Ishikawa, Kazuyuki Ueno & Akihiro Yachie

  2. Department of Dermatology, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

    Yasuhito Hamaguchi & Kazuhiko Takehara

Authors
  1. Tadafumi Yokoyama
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  2. Masaki Shimizu
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  3. Sayaka Ishikawa
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  4. Kazuyuki Ueno
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  5. Yasuhito Hamaguchi
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  6. Kazuhiko Takehara
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  7. Akihiro Yachie
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Corresponding author

Correspondence to Masaki Shimizu.

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Yokoyama, T., Shimizu, M., Ishikawa, S. et al. Accumulation of mature B cells in the inflamed muscle tissue of a patient with anti-155/140 antibody-positive juvenile dermatomyositis. Mod Rheumatol 23, 167–171 (2013). https://doi.org/10.1007/s10165-012-0627-8

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  • DOI: https://doi.org/10.1007/s10165-012-0627-8

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