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ANCA-associated vasculitis with dual ANCA positivity in coexistence with mixed connective tissue disease

  • Case Report
  • Published:
Modern Rheumatology

Abstract

We here report a rare case of dual antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a 38-year-old Japanese woman previously diagnosed with mixed connective tissue disease. The patient was found to be positive for myeloperoxidase- and proteinase 3-ANCA, and was diagnosed with AAV following admission to hospital with fervescence, polyarthralgia, purpura, and asymmetric numbness of the extremities. Examination of her genetic background revealed that she carried HLA-DR9, which confers risk of both diseases in Japanese populations.

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Authors and Affiliations

  1. Department of Rheumatology, Tokyo Metropolitan Bokutoh Hospital, 4-23-15 Kotobashi, Sumida-Ku, Tokyo, 130-8575, Japan

    Masanori Murakami, Kenichi Shimane, Hiroshi Takahashi & Masakazu Nagashima

  2. Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan

    Junji Tomiyama

Authors
  1. Masanori Murakami
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  2. Kenichi Shimane
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  3. Hiroshi Takahashi
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  4. Junji Tomiyama
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  5. Masakazu Nagashima
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Correspondence to Kenichi Shimane.

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Murakami, M., Shimane, K., Takahashi, H. et al. ANCA-associated vasculitis with dual ANCA positivity in coexistence with mixed connective tissue disease. Mod Rheumatol 23, 156–161 (2013). https://doi.org/10.1007/s10165-012-0619-8

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  • DOI: https://doi.org/10.1007/s10165-012-0619-8

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