Skip to main content

Advertisement

SpringerLink
Log in

Etanercept is safely used for treating psoriatic arthritis in a patient complicated with type 1 hereditary angioedema

  • Case Report
  • Published:
Modern Rheumatology

Abstract

Hereditary angioedema (HAE) is a life-threatening disorder caused by deficiency or dysfunction of the C1 inhibitor protein. Patients with HAE are restricted in various medical treatments, which can induce an HAE attack. We herein report the first case of psoriatic arthritis (PSA) with type 1 HAE successfully treated with 25 mg of etanercept without HAE attack. Etanercept may represent a useful choice for treating patients with HAE accompanied by intractable PSA and rheumatoid arthritis (RA).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Agostoni A, Cicardi M. Hereditary and acquired C1-inhibitor deficiency: biological and clinical characteristics in 235 patients. Medicine (Baltimore). 1993;71:206–15.

    Google Scholar 

  2. Parish LC. Hereditary angioedema: diagnosis and management—a perspective for the dermatologist. J Am Acad Dermatol. 2011 (Epub).

  3. Lock RJ, Gompels MM. C1-inhibitor deficiencies (hereditary angioedema): where are we with therapies? Curr Allergy Asthma Rep. 2007;7:264–9.

    Article  PubMed  CAS  Google Scholar 

  4. Rottem M, Mader R. Successful use of etanercept in acquired angioedema in a patient with psoriatic arthritis. J Rheumatol. 2010;37(1):209.

    Article  PubMed  Google Scholar 

  5. Horiuchi T, Mitoma H, Harashima S, Tsukamoto H, Shimoda T. Transmembrane TNF-alpha: structure, function and interaction with anti-TNF agents. Rheumatology (Oxford). 2010;49:1215–28.

    Article  CAS  Google Scholar 

  6. Mitoma H, Horiuchi T, Tsukamoto H, Tamimoto Y, Kimoto Y, Uchino A, To K, Harashima S, Hatta N, Harada M. Mechanisms for cytotoxic effects of anti-tumor necrosis factor agents on transmembrane tumor necrosis factor alpha-expressing cells: comparison among infliximab, etanercept, and adalimumab. Arthritis Rheum. 2008;58(5):1248–57.

    Article  PubMed  CAS  Google Scholar 

  7. Yamamoto T, Horiuchi T, Miyahara H, Yoshizawa S, Maehara J, Shono E, Takamura K, Machida H, Tsujioka K, Kaneko T, Uemura N, Suzawa K, Inagaki N, Umegaki N, Kasamatsu Y, Hara A, Arinobu Y, Inoue Y, Niiro H, Kashiwagai Y, Harashima SI, Tahira T, Tsukamoto H, Akashi K. Hereditary angioedema in Japan: genetic analysis of 13 unrelated cases. Am J Med Sci. 2012 [Epub ahead of print]

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Dermatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, Japan

    Noriko Umegaki, Masahiro Kira, Saori Itoi, Mamori Tani, Akinori Yokomi, Atsushi Tanemura & Ichiro Katayama

  2. Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

    Takahiko Horiuchi

  3. NHO Kyushu Medical Center, Fukuoka, Japan

    Hisaaki Miyahara

  4. Department of Medical Technology, Faculty of Health Sciences, Kobe Tokiwa University, Kobe, Japan

    Michiyo Hatanaka, Hajime Kitamura & Etsuko Kitano

Authors
  1. Noriko Umegaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masahiro Kira
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takahiko Horiuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Saori Itoi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mamori Tani
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Akinori Yokomi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Atsushi Tanemura
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hisaaki Miyahara
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Michiyo Hatanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Hajime Kitamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Etsuko Kitano
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Ichiro Katayama
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Masahiro Kira.

About this article

Cite this article

Umegaki, N., Kira, M., Horiuchi, T. et al. Etanercept is safely used for treating psoriatic arthritis in a patient complicated with type 1 hereditary angioedema. Mod Rheumatol 22, 928–930 (2012). https://doi.org/10.1007/s10165-012-0604-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10165-012-0604-2

Keywords

Search

Navigation