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Syndrome of inappropriate secretion of antidiuretic hormone induced by tacrolimus in a patient with systemic lupus erythematosus

  • Case Report
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Modern Rheumatology

Abstract

We describe the first reported case of a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) induced by low-dose tacrolimus in a patient with autoimmune disease. A 41-year-old man with systemic lupus erythematosus (SLE) developed hyponatremia induced by SIADH after administration of tacrolimus (0.06 mg/kg per day). In this case, the hyponatremia promptly resolved upon withdrawal of tacrolimus. This case strongly suggests that SIADH is a potentially important complication of tacrolimus administration, irrespective of dosage, and should be borne in mind whenever the drug is used.

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Authors and Affiliations

  1. Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan

    Koichiro Suemori, Hitoshi Hasegawa, Masashi Kohno, Takuya Matsumoto, Yusuke Kawamoto & Masaki Yasukawa

  2. Department of Dermatology, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan

    Chika Nanba, Shinji Murakami & Koji Hashimoto

  3. Department of Medical Technology, Ehime Prefectural University of Health Sciences, Takoda 543, Tobe, Iyo, Ehime, 791-2101, Japan

    Eiji Sada

Authors
  1. Koichiro Suemori
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  2. Hitoshi Hasegawa
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  3. Chika Nanba
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  4. Masashi Kohno
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  5. Takuya Matsumoto
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  6. Yusuke Kawamoto
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  7. Shinji Murakami
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  8. Eiji Sada
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  9. Koji Hashimoto
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  10. Masaki Yasukawa
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Correspondence to Koichiro Suemori.

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Suemori, K., Hasegawa, H., Nanba, C. et al. Syndrome of inappropriate secretion of antidiuretic hormone induced by tacrolimus in a patient with systemic lupus erythematosus. Mod Rheumatol 21, 97–100 (2011). https://doi.org/10.1007/s10165-010-0350-2

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  • DOI: https://doi.org/10.1007/s10165-010-0350-2

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