Abstract
A 58-year-old woman was diagnosed with Churg–Strauss syndrome (CSS) based on the symptoms of bronchial asthma, eosinophilia, mononeuritis multiplex and histological examination of the right sural nerve. Prior to treatment, the serum interleukin (IL)-5 level was high, and rearrangement of the T cell receptor (TCR) gene was identified. This is the first report of TCR gene rearrangement in a patient with CSS. The expanded T cell clone may be responsible for the overproduction of IL-5. Further studies are warranted to disclose a prevalence of TCR gene rearrangement in CSS patients and its pathophysiological roles in the development of this disease.
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Horai, Y., Miyamura, T., Takahama, S. et al. Churg–Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-Cβ gene rearrangement. Mod Rheumatol 21, 76–78 (2011). https://doi.org/10.1007/s10165-010-0341-3
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DOI: https://doi.org/10.1007/s10165-010-0341-3