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Neutrophil CD64 expression as a diagnostic marker for local infection and crystal-induced arthritis

  • Original Article
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Modern Rheumatology

Abstract

The usefulness of neutrophil CD64 expression was examined in diagnosing local infection, including soft tissue, bone, and joint infections. Among 99 patients suspected of local infection, 31 were confirmed and 68 patients were not. The CD64 level of patients with local infection was significantly higher than in those without infection [4,193 ± 1,132 vs. 1,017 ± 59 molecules/cell (mean ± standard deviation); p < 0.001]. The area under the curve of CD64 calculated by receiver operating characteristic curve analysis was larger than that of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), or white blood cell (WBC) count. In addition, CD64 levels of patients with crystal-induced arthritis remained within cutoff value (2,000 molecules/cell). These data suggest that measuring CD64 expression can be a useful diagnostic marker for local musculoskeletal infection and crystal-induced arthritis.

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Acknowledgments

The authors thank Ms. Yuko Hotta and Ms. Chisato Kawabata who provided expert technical assistance. The authors wish to acknowledge the assistance of the following clinicians who referred patients to this study: Dr. Yuho Kadono, Dr. Jun Hirose, Dr. Takuji Hirose, Dr. Katsumi Itoh, Dr. Takuo Juji, Dr. Masahito Koiwa, Dr. Yosiaki Kuga, Dr. Takeshi Matsumoto, Dr. Shouichi Nagashima, Dr. Ichiro Nakamura, Dr. Junji Oda, and Dr. Shouji Sugii. This study was in part supported by Grants-in-Aid from the Health Science research grants from the Ministry of Health, Labor, and Welfare of Japan to S. Tohma and grant from the National Hospital Organization to T. Matsui.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan

    Toru Doi, Tsuyoshi Miyazaki, Seizo Yamamoto & Fumiaki Tokimura

  2. Nishino Clinic Orthopedics and Rheumatology, 2-9-15 Nishigaoka, Kita-ku, Tokyo, 115-0056, Japan

    Jinju Nishino

  3. Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8605, Japan

    Sakae Tanaka

  4. Department of Rheumatology, Sagamihara National Hospital, National Hospital Organization (NHO), 18-1 Sakuradai, Sagamihara, Kanagawa, 228-8522, Japan

    Toshihiro Matsui, Akiko Komiya & Shigeto Tohma

  5. Department of Orthopaedic Surgery, Sagamihara National Hospital, National Hospital Organization (NHO), 18-1 Sakuradai, Sagamihara, Kanagawa, 228-8522, Japan

    Toshihito Mori

  6. Department of Orthopaedic Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan

    Keita Nishimura, Narutaka Katoh & Takashi Matsushita

  7. Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, 2-9-2 Musashidai, Fuchu, Tokyo, 183-8524, Japan

    Jun Hasegawa & Yasunori Omata

Authors
  1. Toru Doi
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  2. Tsuyoshi Miyazaki
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  3. Jinju Nishino
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  4. Sakae Tanaka
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  5. Toshihiro Matsui
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  6. Akiko Komiya
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  7. Seizo Yamamoto
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  8. Fumiaki Tokimura
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  9. Toshihito Mori
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  10. Keita Nishimura
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  11. Narutaka Katoh
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  12. Jun Hasegawa
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  13. Yasunori Omata
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  14. Takashi Matsushita
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  15. Shigeto Tohma
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Corresponding author

Correspondence to Sakae Tanaka.

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Cite this article

Doi, T., Miyazaki, T., Nishino, J. et al. Neutrophil CD64 expression as a diagnostic marker for local infection and crystal-induced arthritis. Mod Rheumatol 20, 573–579 (2010). https://doi.org/10.1007/s10165-010-0322-6

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  • DOI: https://doi.org/10.1007/s10165-010-0322-6

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