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Marked effect and steroid-sparing ability of anakinra on a patient with refractory adult-onset Still’s disease

  • Case Report
  • Published:
Modern Rheumatology

Abstract

We report a case of refractory adult-onset Still’s disease (AOSD) successfully controlled with anakinra, an interleukin-1 (IL-1) receptor antagonist. The patient was a 23-year-old Japanese woman with AOSD who could not be induced into remission despite of two courses of pulsed methylprednisolone followed by high-dose glucocorticoid administration in conjunction with high-dose intravenously administered γ-globulin and methotrexate. To the best of our knowledge, this is the first case report in Japan of AOSD remission induced with anakinra.

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Authors and Affiliations

  1. Section of Allergy and Rheumatology, St. Luke’s International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan

    Hiromichi Tamaki, Hisanori Shimizu, Eishi Uechi, Mitsumasa Kishimoto, Kenichi Yamaguchi & Masato Okada

  2. Department of General Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

    Eiji Hiraoka

Authors
  1. Hiromichi Tamaki
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  2. Hisanori Shimizu
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  3. Eiji Hiraoka
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  4. Eishi Uechi
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  5. Mitsumasa Kishimoto
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  6. Kenichi Yamaguchi
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  7. Masato Okada
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Correspondence to Hiromichi Tamaki.

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Tamaki, H., Shimizu, H., Hiraoka, E. et al. Marked effect and steroid-sparing ability of anakinra on a patient with refractory adult-onset Still’s disease. Mod Rheumatol 20, 200–204 (2010). https://doi.org/10.1007/s10165-009-0254-1

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  • DOI: https://doi.org/10.1007/s10165-009-0254-1

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