Skip to main content

Advertisement

SpringerLink
Log in

Administration of human immunoglobulin suppresses development of murine systemic vasculitis induced with Candida albicans water-soluble fraction: an animal model of Kawasaki disease

  • Original Article
  • Published:
Modern Rheumatology

Abstract

We investigated the inhibitory effect of human immunoglobulin (h-Ig) on the development of coronary arteritis in a murine model of vasculitis induced with a Candida albicans water-soluble fraction (CAWS). CAWS was intraperitoneally injected to C57BL/6 mice for 5 days. Then h-Ig was administered according to various schedules. The animals were sacrificed in week 5, and the status of vasculitis in the coronary arteries and the aortic root was investigated histologically. The groups in which h-Ig was administered for 5 days from day 3 and from day 5 of the experiment showed a significant reduction in the incidence of panvasculitis. In addition, the scope and severity of the inflammation of the aortic root and the coronary arteries were reduced in both groups. In the group administered h-Ig for 5 days from day 1 and the group administered a high dose of h-Ig once on day 1 or day 3, no suppression of development of vasculitis was observed. The h-Ig acted by suppressing the generation and progression of vasculitis in this CAWS-induced murine vasculitis model.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Kawasaki T. Acute febrile muco-cutaneous lymph node syndrome in young children with unique digital desquamation. Jpn J Allergol. 1967;16:178–222.

    CAS  Google Scholar 

  2. Kawasaki T, Kosaki F, Okawa S, Shigematsu I, Yanagawa H. New infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics. 1974;54:271–6.

    CAS  PubMed  Google Scholar 

  3. Nakamura Y, Yashiro M, Uehara R, Oki I, Kayaba K, Yanagawa H. Increasing incidence of Kawasaki disease in Japan: nationwide survey. Pediatr Int. 2008;50:287–90.

    Article  PubMed  Google Scholar 

  4. Naoe S, Takahashi K, Masuda H, et al. Kawasaki disease with particular emphasis on arterial lesions. Acta Pathol Jpn. 1991;41:785–97.

    CAS  PubMed  Google Scholar 

  5. Murata H. Experimental Candida-induced arteritis in mice. Relation to arteritis in the mucocutaneous lymph node syndrome. Microbiol Immunol. 1979;23:825–31.

    CAS  PubMed  Google Scholar 

  6. Murata H, Iijima H, Naoe S, Atobe T, Uchiyama S, Arakawa S. The pathogenesis of experimental arteritis induced by Candida alkali extract in mice. Jpn J Exp Med. 1987;57:305–13.

    CAS  PubMed  Google Scholar 

  7. Takahashi K, Oharaseki T, Wakayama M, Yokouchi Y, Naoe S, Murata H. Histopathological features of murine systemic vasculitis caused by Candida albicans extract—an animal model of Kawasaki disease. Inflamm Res. 2004;53:72–7.

    Article  CAS  PubMed  Google Scholar 

  8. Kurihara K, Miura NN, Uchiyama M, Ohno N, Adachi Y, Aizawa M, et al. Measurement of blood clearance time by Limulus G test of Candida water-soluble polysaccharide fraction, CAWS, in mice. FEMS Immunol Med Microbiol. 2000;29:69–76.

    Article  CAS  PubMed  Google Scholar 

  9. Kurihara K, Shingo Y, Miura NN, Horie S, Usui Y, Adachi Y, et al. Effect of CAWS, a mannoprotein–beta-glucan complex of Candida albicans, on leukocyte, endothelial cell, and platelet functions in vitro. Biol Pharm Bull. 2003;26:233–40.

    Article  CAS  PubMed  Google Scholar 

  10. Uchiyama M, Ohno N, Miura NN, Adachi Y, Aizawa MW, Tamura H. Chemical and immunochemical characterization of limulus factor G-activating substance of Candida spp. FEMS Immunol Med Microbiol. 1999;24:411–20.

    Article  CAS  PubMed  Google Scholar 

  11. Miura NN, Shingo Y, Adachi Y, Okawara IA, Oharaseki T, Takahashi K, et al. Induction of coronary arteritis with administration of CAWS (Candida albicans water soluble fraction) depending on mouse strains. Immunopharmacol Immunotoxicol. 2004;26:527–43.

    Article  Google Scholar 

  12. Miura NN, Harada T, Shinohara H, Kurihara K, Adachi Y, Okawara IA, et al. Lethal and severe coronary arteritis in DBA/2 mice induced by fungal pathogen, CAWS, Candida albicans water-soluble fraction. Atherosclerosis. 2006;186:310–20.

    Article  CAS  Google Scholar 

  13. Oharaseki T, Kameoka Y, Kura F, Persad AS, Suzuki K, Naoe S. Susceptibility loci to coronary arteritis in animal model of Kawasaki disease induced with Candida albicans-derived substances. Microbiol Immunol. 2005;49:181–9.

    CAS  PubMed  Google Scholar 

  14. Okawara AI, Miura NN, Oharaseki T, Takahashi K, Okumra A, Tachikawa H, et al. Neutrophil activation and arteritis induced by C. albicans water-soluble mannoprotein–β-glucan complex (CAWS). Exp Mol Pathol. 2007;82:220–6.

    Article  CAS  Google Scholar 

  15. Furusho K, Kamiya T, Nakano H, Kiyosawa N, Shinomiya K, Hayashidera T, et al. High-dose intravenous gammaglobulin for Kawasaki disease. Lancet. 1984;10:1055–8.

    Article  Google Scholar 

  16. Newburger JW, Takahashi M, Beiser AS, Burns JC, Bastian J, Chung KJ, et al. A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome. N Engl J Med. 1991;324:1633–9.

    Article  CAS  PubMed  Google Scholar 

  17. Danieli MG, Cappelli M, Malcangi G, Logullo F, Salvi A, Danieli G. Long term effectiveness of intravenous immunoglobulin in Churg-Strauss syndrome. Ann Rheum Dis. 2004;63:1649–54.

    Article  CAS  PubMed  Google Scholar 

  18. Jayne DR, Lockwood CM. Intravenous immunoglobulin as sole therapy for systemic vasculitis. Br J Rheumatol. 1996;35:1150–3.

    Article  CAS  PubMed  Google Scholar 

  19. Levy Y, Uziel Y, Zandman GG, Amital H, Sherer Y, Langevitz P, et al. Intravenous immunoglobulin in peripheral neuropathy associated with vasculitis. Ann Rheum Dis. 2003;62:1221–3.

    Article  CAS  PubMed  Google Scholar 

  20. Ihara IT, Ono T, Nogaki F, Suyama K, Tanaka M, Yonemoto S, et al. Clinical efficacy of intravenous immunoglobulin for patients with MPO-ANCA-associated rapidly progressive glomerulonephritis. Nephron Clin Pract. 2006;102:c35–42.

    Article  CAS  Google Scholar 

  21. Jayne DR, Chapel H, Adu D, Misbah S, O’Donoghue D, Scott D, et al. Intravenous immunoglobulin for ANCA-associated systemic vasculitis with persistent disease activity. Q J Med. 2000;93:433–9.

    CAS  Google Scholar 

  22. Suzuki K, Okazaki T. Contribution of myeloperoxidase in vasculitis development. Jpn J Infect Dis. 2004;57:S2–4.

    PubMed  Google Scholar 

  23. Okawara IA, Oharaseki T, Takahashi K, Hashimoto Y, Aratani Y, Koyama H, et al. Contribution of myeloperoxidase to coronary artery vasculitis associated with MPO–ANCA production. Inflammation. 2001;25:381–7.

    Article  Google Scholar 

  24. Newburger JW, Takahashi M, Burns JC, Beiser AS, Chung KJ, Duffy CE, et al. The treatment of Kawasaki syndrome with intravenous gamma globulin. New Engl J Med. 1986;315:341–6.

    CAS  PubMed  Google Scholar 

  25. Fujii A, Tomizawa A, Arimura Y, Nagasawa T, Ohashi YY, Hiyama T, et al. Epitope analysis of myeloperoxidase (MPO) specific antineutrophil cytoplasmic autoantibodies (ANCA) in MPO–ANCA-associated glomerulonephritis. Clin Nephrol. 2000;53:242–52.

    CAS  PubMed  Google Scholar 

  26. Tomizawa K, Mine E, Fujii A, Ohashi YY, Yamagoe S, Hashimoto Y, et al. A panel set for epitope analysis of myeloperoxidase (MPO)-specific antineutrophil cytoplasmic antibody MPO–ANCA using recombinant hexamer histidine-tagged MPO deletion mutants. J Clin Immunol. 1998;18:142–52.

    Article  CAS  PubMed  Google Scholar 

  27. Suzuki K, Kobayashi S, Yamazaki K, Gondo M, Tomizawa K, Arimura Y, et al. Analysis of risk epitopes of anti-neutrophil antibody MPO–ANCA in vasculitis in Japanese population. Microbiol Immunol. 2007;51:1215–20.

    CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors thank Ms. Hitomi Yamada and Mr. Yoshiaki Kaneshiro for their excellent technical assistance and helpful suggestions. This study was supported in part by a grant from the Japanese Ministry of Health, Labor, and Welfare.

Conflict of interest statement

None.

Author information

Authors and Affiliations

  1. Department of Pathology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro, Tokyo, 153-8515, Japan

    Kei Takahashi, Toshiaki Oharaseki, Yuki Yokouchi, Hisao Murata & Shiro Naoe

  2. Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, 192-0392, Japan

    Noriko N. Miura & Naohito Ohno

  3. Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku, Tokyo, 162-8640, Japan

    Akiko I. Okawara

  4. Department of Immunology, National Institute of Infectious Diseases, Shinjuku, Tokyo, 162-8640, Japan

    Kazuo Suzuki

  5. Inflammation Program, Department of Immunology, Chiba University Graduate School of Medicine, Chiba, Chiba, 260-8670, Japan

    Kazuo Suzuki

Authors
  1. Kei Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Toshiaki Oharaseki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yuki Yokouchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Noriko N. Miura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Naohito Ohno
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Akiko I. Okawara
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hisao Murata
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Shiro Naoe
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Kazuo Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kei Takahashi.

About this article

Cite this article

Takahashi, K., Oharaseki, T., Yokouchi, Y. et al. Administration of human immunoglobulin suppresses development of murine systemic vasculitis induced with Candida albicans water-soluble fraction: an animal model of Kawasaki disease. Mod Rheumatol 20, 160–167 (2010). https://doi.org/10.1007/s10165-009-0250-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10165-009-0250-5

Keywords

Search

Navigation