Skip to main content

Advertisement

SpringerLink
Log in

Acute-onset sarcoidosis with polyarthralgia and hilar lymphadenopathy

  • Case Report
  • Published:
Modern Rheumatology

Abstract

A 33-year-old man was admitted to our hospital because of fever and arthralgia. Radiographic findings revealed bilateral hilar lymphadenopathy (BHL) and enlargement of lymph nodes of the mediastinum. Tissue from a mediastinum lymph node showed noncaseating granulomas. An acute form of sarcoidosis, Lofgren’s syndrome, was diagnosed. Prednisolone was administered. Because this syndrome is rare in Japan, histopathological examination was necessary to diagnose and treat this patient.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Newman LS, Rose CS, Maier LA. Sarcoidosis. N Engl J Med. 1997;336:1224–34.

    Article  CAS  PubMed  Google Scholar 

  2. Karina DT, Francisco PQ Jr. Sarcoid arthritis: a review of clinical features, pathology and therapy. Diffuse Lung Dis. 2003;20:95–103.

    Google Scholar 

  3. Izumo M, Sekiya K, Sakai T, Tojima H. A male case of acute sarcoidosis with fever polyarthralgia, erythema nodosum, and bilateral hilar lymphadenopathy: Lofgren’s syndrome. Nihon Kokyuki Gakkai Zasshi. 2005;43:761–5. (in Japanese, Abstract in English).

    PubMed  Google Scholar 

  4. Lofgren S. Primary pulmonary sarcoidosis. II Clinical course and prognosis. Acta Med Scand. 1953;45:465–74.

    Google Scholar 

  5. Caplan HI, Katz WA, Rubenstein M. Periarticular inflammation bilateral hilar adenopathy and sarcoid reaction. Arthritis Care Res. 1970;13:101–11.

    Article  CAS  Google Scholar 

  6. Grunewald J, Eklund A. Sex-specific manifestations of Lofgren’s syndrome. Am J Respir Crit Care Med. 2007;175:40–4.

    Article  CAS  PubMed  Google Scholar 

  7. Mana J, Gormez-Vaquero C, Montero A, Salazar A, Marcoval J, Valverde J, et al. Lofgren’s syndrome revisited: a study of 186 patients. Am J Med. 1999;107:240–5.

    Article  CAS  PubMed  Google Scholar 

  8. Glennas A, Kvein TK, Melby K, Refvem OK, Andrup O, Karstensen B, et al. Acute sarcoid arthritis: occurrence, seasonal onset, clinical features and outcome. Br J Rheumatol. 1995;34:45–50.

    Article  CAS  PubMed  Google Scholar 

  9. Mana J, Salazar A, Pujol R, Manresa F. Are the pulmonary function tests and the markers of activity helpful to establish the prognosis of sarcoidosis? Respiration. 1996;63:298–303.

    Article  CAS  PubMed  Google Scholar 

  10. Ando M. Recent epidemiological features of sarcoidosis in Japan (in Japanese, Abstract in English). Nippon Rinsho. 1994;52:1433–7.

    CAS  PubMed  Google Scholar 

  11. Hedfors E, Lindstrom F. HLA-B8/DR3 in sarcoidosis. Correlation to acute onset disease with arthritis. Tissue Antigens. 1983;22:200–3.

    Article  CAS  PubMed  Google Scholar 

  12. Kunikane H, Abe S, Tsuneta Y, Nakayama T, Tajima Y, Misonou J, et al. Role of HLA-DR antigens in Japanese Patients with Sarcoidosis. Am Rev Respir Dis. 1987;135:688–91.

    CAS  PubMed  Google Scholar 

  13. Sato T, Tsuru T, Hagiwara K, Miyazshita K, Mstsuno H, Goto A, et al. Sarcoidosis with acute recurrent polyarthritis and hypercalcemia. Intern Med. 2006;45:363–8.

    Article  PubMed  Google Scholar 

  14. Ohta H, Tazawa R, Nakamura A, Kimura Y, Maemondo M, Kikuchi T, et al. Acute-onset sarcoidosis with erythema nodosum and polyarthralgia (Lofgren’s syndrome) in Japan: case report and review of the literature. Intern Med. 2006;45:659–62.

    Article  PubMed  Google Scholar 

Download references

Acknowledgment

We thank Dr. Akito Tsutsumi (Takikawa Municipal Hospital) for assistance in editing the manuscript.

Conflict of interest statement

None.

Author information

Authors and Affiliations

  1. Division of Rheumatology, Ohta-Nishinouchi Hospital, Koriyama, Japan

    Eiji Suzuki & Takashi Kanno

  2. Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan

    Eiji Suzuki & Hiromasa Ohira

Authors
  1. Eiji Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takashi Kanno
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hiromasa Ohira
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eiji Suzuki.

About this article

Cite this article

Suzuki, E., Kanno, T. & Ohira, H. Acute-onset sarcoidosis with polyarthralgia and hilar lymphadenopathy. Mod Rheumatol 20, 188–192 (2010). https://doi.org/10.1007/s10165-009-0248-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10165-009-0248-z

Keywords

Search

Navigation