Abstract
We present an adult patient with Henoch-Schönlein Purpura who developed mononeuropathy in the common peroneal nerve. Upon admission, the patient had palpable purpura in the arms and legs, polyarthralgia, abdominal pain, and leukocytoclastic vasculitis in the skin biopsy. These symptoms disappeared with 30 mg daily of oral prednisolone. One month later, after induction therapy, fever, livedo reticularis and peripheral mononeuropathy developed with hypocomplementemia and the patient was treated successfully with glucocorticoid pulse therapy.
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10165-008-0121-5/MediaObjects/10165_2008_121_Fig1_HTML.jpg)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10165-008-0121-5/MediaObjects/10165_2008_121_Fig2_HTML.gif)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10165-008-0121-5/MediaObjects/10165_2008_121_Fig3_HTML.jpg)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10165-008-0121-5/MediaObjects/10165_2008_121_Fig4_HTML.gif)
Similar content being viewed by others
References
Lie JT. Illustrated histopathologic classification criteria for selected vasculitis syndromes. American College of Rheumatology subcommittee on classification of vasculitis. Arthritis Rheum. 1990;33(8):1074–87.
Blanco R, Martinez-Taboada VM, Rodriguez-Valverde V, Garcia-Fuentes M, Gonzalez-Gay MA. Henoch-Schönlein purpura in adulthood and childhood: two different expressions of the same syndrome. Arthritis Rheum. 1997;40(5):859–64.
Tancrede-Bohin E, Ochonisky S, Vignon-Pennamen MD, Flageul B, Morel P, Rybojad M. Schönlein-Henoch purpura in adult patients. Predictive factors for IgA glomerulonephritis in a retrospective study of 57 cases. Arch Dermatol. 1997;133(4):438–42.
Ballinger S. Henoch-Schönlein purpura. Curr Opin Rheumatol. 2003;15(5):591–4.
Fervenza FC. Henoch-Schönlein purpura nephritis. Int J Dermatol. 2003;42(3):170–7.
Belman AL, Leicher CR, Moshe SL, Mezey AP. Neurologic manifestations of Schönlein-Henoch purpura: report of three cases and review of the literature. Pediatrics. 1985;75(4):687–92.
Ritter FJ, Seay AR, Lahey ME. Peripheral mononeuropathy complicating anaphylactoid purpura. J Pediatr. 1983;103(1):77–8.
Mutsukura K, Tsuboi Y, Fujiki F, Fujioka S, Inoue H, Yamada T. Acute motor sensory axonal neuropathy associated with Henoch-Schönlein purpura. J Neurol Sci. 2007;263(1-2):169–73.
Mills JA, Michel BA, Bloch DA, Calabrese LH, Hunder GG, Arend WP, et al. The American College of Rheumatology 1990 criteria for the classification of Henoch-Schönlein purpura. Arthritis Rheum. 1990;33(8):1114–21.
Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, Gross WL, et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum. 1994;37(2):187–92.
Jennette JC, Falk RJ. Small-vessel vasculitis. N Engl J Med. 1997;337(21):1512–23.
Cream JJ, Gumpel JM, Peachey RD. Schönlein-Henoch purpura in the adult. A study of 77 adults with anaphylactoid or Schönlein-Henoch purpura. Q J Med. 1970;39(156):461–84.
Kellerman PS. Henoch-Schönlein purpura in adults. Am J Kidney Dis. 2006;48(6):1009–16.
Matteson EL. Notes on the history of eponymic idiopathic vasculitis: the diseases of Henoch and Schönlein, Wegener, Churg and Strauss, Horton, Takayasu, Behçet, and Kawasaki. Arthritis Care Res. 2000;13(4):237–45.
Saulsbury FT. Epidemiology of Henoch-Schönlein purpura. Cleve Clin J Med. 2002;69(Suppl 2):SII87–9.
Garcia-Fuentes M, Martin A, Chantler C, Williams DG. Serum complement components in Henoch-Schönlein purpura. Arch Dis Child. 1978;53(5):417–9.
Motoyama O, Iitaka K. Henoch-Schönlein purpura with hypocomplementemia in children. Pediatr Int. 2005;47(1):39–42.
Carlson JA, Chen KR. Cutaneous vasculitis update: small-vessel neutrophilic vasculitis syndromes. Am J Dermatopathol. 2006;28(6):486–506.
Stone JH, Nousari HC. “Essential” cutaneous vasculitis: what every rheumatologist should know about vasculitis of the skin. Curr Opin Rheumatol. 2001;13(1):23–34.
Rantapaa-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48(10):2741–9.
Mitsuhashi H, Mitsuhashi M, Tsukada Y, Yano S, Naruse T. Henoch-Schönlein purpura in rheumatoid arthritis. J Rheumatol. 1994;21(6):1138–40.
Cho CS, Min JK, Park SH, Yang HI, Lee SH, Choi YJ, et al. Protein-losing enteropathy associated with Henoch-Schönlein purpura in a patient with rheumatoid arthritis. Scand J Rheumatol. 1996;25(5):334–6.
Sanchez-Perez J, Fernandez-Herrera J, Sols M, Jones M, Garcia Diez A. Leucocytoclastic vasculitis in subacute cutaneous lupus erythematosus. Br J Dermatol. 1993;128(4):469–70.
Cacoub P, Costedoat-Chalumeau N, Lidove O, Alric L. Cryoglobulinemia vasculitis. Curr Opin Rheumatol. 2002;14(1):29–35.
Islek I, Muslu A, Totan M, Gok F, Sanic A. Henoch-Schönlein purpura and pulmonary tuberculosis. Pediatr Int. 2002;44(5):545–6.
Madison DL, Allen E, Deodhar A, Morrison L. Henoch-Schönlein purpura: a possible complication of hepatitis C related liver cirrhosis. Ann Rheum Dis. 2002;61(3):281–2.
Masuda M, Nakanishi K, Yoshizawa N, Iijima K, Yoshikawa N. Group A streptococcal antigen in the glomeruli of children with Henoch-Schönlein nephritis. Am J Kidney Dis. 2003;41(2):366–70.
Hunder G. Vasculitis: diagnosis and therapy. Am J Med. 1996;100(2A):37S–45S.
Leavitt RY, Fauci AS. Polyangiitis overlap syndrome. Classification and prospective clinical experience. Am J Med. 1986;81(1):79–85.
Watanabe K, Abe H, Mishima T, Ogura G, Suzuki T. Polyangitis overlap syndrome: a fatal case combined with adult Henoch-Schönlein purpura and polyarteritis nodosa. Pathol Int. 2003;53(8):569–73.
Lightfoot RW Jr, Michel BA, Bloch DA, Hunder GG, Zvaifler NJ, McShane DJ, et al. The American College of Rheumatology 1990 criteria for the classification of polyarteritis nodosa. Arthritis Rheum. 1990;33(8):1088–93.
Pertuiset E, Liote F, Launay-Russ E, Kemiche F, Cerf-Payrastre I, Chesneau AM. Adult Henoch-Schönlein purpura associated with malignancy. Semin Arthritis Rheum. 2000;29(6):360–7.
Pillebout E, Thervet E, Hill G, Alberti C, Vanhille P, Nochy D. Henoch-Schönlein Purpura in adults: outcome and prognostic factors. J Am Soc Nephrol. 2002;13(5):1271–8.
Costner MI, Sontheiner RP. Lupus-nonspecific skin disease. In: Wallace DJ, Hahn BH, editors. Dubois’ Lupus Erythemtosus. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 631.
Bahrami S, Malone JC, Webb KG, Callen JP. Tissue eosinophilia as an indicator of drug-induced cutaneous small-vessel vasculitis. Arch Dermatol. 2006;142(2):155–61.
Nadrous HF, Yu AC, Specks U, Ryu JH. Pulmonary involvement in Henoch-Schönlein purpura. Mayo Clin Proc. 2004;79(9):1151–7.
Ozaltin F, Bakkaloglu A, Ozen S, Topaloglu R, Kavak U, Kalyoncu M, et al. The significance of IgA class of antineutrophil cytoplasmic antibodies (ANCA) in childhood Henoch-Schönlein purpura. Clin Rheumatol. 2004;23(5):426–9.
Rovel-Guitera P, Diemert MC, Charuel JL, Laporte JL, Musset L, Chosidow O, et al. IgA antineutrophil cytoplasmic antibodies in cutaneous vasculitis. Br J Dermatol. 2000;143(1):99–103.
Weiss PF, Feinstein JA, Luan X, Burnham JM, Feudtner C. Effects of corticosteroid on Henoch-Schönlein purpura: a systematic review. Pediatrics. 2007;120(5):1079–87.
Acknowledgments
This work was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan (K.O. and C.M.) and the Ministry of Health, Labour and Welfare, Japan (C.M.). Support was also provided by the Program of Promotion of Fundamental Studies in Health Science of the National Institute of Biomedical Innovation (C.M.).
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Ohnuma, K., Hosono, O., Kawasaki, H. et al. An adult case of Henoch-Schönlein purpura complicating common peroneal nerve mononeuropathy. Mod Rheumatol 19, 73–79 (2009). https://doi.org/10.1007/s10165-008-0121-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10165-008-0121-5