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A sudden onset of diabetic ketoacidosis and acute pancreatitis after introduction of mizoribine therapy in a patient with rheumatoid arthritis

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Modern Rheumatology

Abstract

Mizoribine has been recognized to have an acceptable toxicity profile compared with other immunosuppressants. In this study, however, we report a case of diabetic ketoacidosis and acute pancreatitis that suddenly occurred in a rheumatoid arthritis patient 2 weeks after introduction of mizoribine therapy. To the best of our knowledge, this is the first case in the literature to show mizoribine-induced diabetic ketoacidosis. Through prompt diagnosis and treatment, the patient recovered from these extremely rare but potentially lethal complications.

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Conflict of interest statement

This research work has received no financial support that may pose any conflicts of interest.

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Authors and Affiliations

  1. Clinical Research Center for Rheumatic Disease and Department of Rheumatology, Kumamoto Saishunsou National Hospital, 2659 Suya, Kohshi, Kumamoto, 861-1196, Japan

    Shunsuke Mori

  2. Division of Metabolic Medicine, Department of Medicine, Kumamoto Saishunsou National Hospital, 2659 Suya, Kohshi, Kumamoto, 861-1196, Japan

    Kenji Ebihara

Authors
  1. Shunsuke Mori
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  2. Kenji Ebihara
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Correspondence to Shunsuke Mori.

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Mori, S., Ebihara, K. A sudden onset of diabetic ketoacidosis and acute pancreatitis after introduction of mizoribine therapy in a patient with rheumatoid arthritis. Mod Rheumatol 18, 634–638 (2008). https://doi.org/10.1007/s10165-008-0106-4

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  • DOI: https://doi.org/10.1007/s10165-008-0106-4

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