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The relationships between titers of anti-Ro or anti-La as measured by ELISA and salivary production rate with age correction

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Modern Rheumatology

Abstract

The objective of this work was to clarify the clinical significance of titers of anti-Ro and anti-La, the relationships between titers of either anti-Ro or anti-La, and salivary production rate (SPR). These autoantibodies were titrated using enzyme-linked immunosorbent assay. The Saxon test was performed to measure SPR. Fifty-one females who had anti-Ro but not anticentromere antibodies or anti-U1RNP were enrolled. SPR decreased significantly with age. In order to exclude the effect of aging on SPR, we calculated the “SPR with age correction.” According to the results of a multiple regression analysis, only the anti-La titer was significantly associated with SPR with age correction. The distribution pattern of the anti-La titers consisted of two subgroups (with a titer index cutoff of 100.0): a negative anti-La titer (anti-La < 25.0) and low anti-La titer (25.0 ≤ anti-La < 100.0) group, and a high anti-La titer group (anti-La ≥ 100.0). The concentration of serum IgG and the frequency of Sjögren’s syndrome in the high anti-La titer group were significantly higher than those in the negative anti-La and low anti-La titer group. Several new aspects of the clinical significance of titrating anti-Ro and anti-La in comparison with SPR have been revealed.

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Conflict of interest statement

We declare that there is no conflict of interest in this paper.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Rheumatology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan

    Kunio Takada, Kimihiro Suzuki, Mitsuyo Matsumoto, Makoto Okada, Takashi Nakanishi, Hideyuki Horikoshi, Tomoaki Higuchi, Akiyoshi Nakayama & Fumitaka Ohsuzu

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  1. Kunio Takada
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  2. Kimihiro Suzuki
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  3. Mitsuyo Matsumoto
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  4. Makoto Okada
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  5. Takashi Nakanishi
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  6. Hideyuki Horikoshi
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  7. Tomoaki Higuchi
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  8. Akiyoshi Nakayama
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  9. Fumitaka Ohsuzu
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Correspondence to Kunio Takada.

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Takada, K., Suzuki, K., Matsumoto, M. et al. The relationships between titers of anti-Ro or anti-La as measured by ELISA and salivary production rate with age correction. Mod Rheumatol 18, 578–584 (2008). https://doi.org/10.1007/s10165-008-0098-0

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  • DOI: https://doi.org/10.1007/s10165-008-0098-0

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