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A case of granuloma in the occipital lobe of a patient with Wegener’s granulomatosis

  • Case Report
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Modern Rheumatology

Abstract

We report a case of Wegener’s granulomatosis (WG) with central nervous system (CNS) involvement in a woman who complained of bilateral visual disturbance. The intracranial necrotizing granulomatous lesion was confirmed by MR imaging and brain biopsy. After high-dose oral corticosteroid treatment, not only clinical manifestations but also laboratory tests improved. Moreover, the CNS lesion completely regressed. This suggests that high-dose corticosteroid alone might be effective in treating WG with CNS involvement.

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Acknowledgments

We thank Dr. Hajime Sano and Dr. Tsuyoshi Iwasaki (Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine) for helpful discussion. We also declare that there are no financial or other relationships that could lead to a conflict of interest.

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Authors and Affiliations

  1. Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan

    Naoto Azuma

  2. Division of Allergy and Clinical Immunology, National Hospital Organization Osaka-Minami Medical Center, 2-1 Kido-Higashi-machi, Kawachinagano, Osaka, 586-8521, Japan

    Naoto Azuma, Yoshinori Katada, Yoshinori Harada & Takao Yamanaka

  3. Division of Neurosurgery, National Hospital Organization Osaka-Minami Medical Center, Kawachinagano, Osaka, Japan

    Nobumasa Nishimura, Tomonori Yamada & Ryunosuke Uranishi

  4. Department of Pathology, National Hospital Organization Osaka-Minami Medical Center, Kawachinagano, Osaka, Japan

    Shinichi Nakatsuka

  5. Division of Neurosurgery, Rinku General Medical Center, Izumisano, Osaka, Japan

    Makoto Dehara

  6. Department of Clinical Investigation, National Hospital Organization Osaka-Minami Medical Center, Kawachinagano, Osaka, Japan

    Yukihiko Saeki

Authors
  1. Naoto Azuma
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  2. Yoshinori Katada
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  3. Nobumasa Nishimura
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  4. Tomonori Yamada
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  5. Ryunosuke Uranishi
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  6. Shinichi Nakatsuka
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  7. Makoto Dehara
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  8. Yoshinori Harada
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  9. Takao Yamanaka
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  10. Yukihiko Saeki
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Corresponding author

Correspondence to Naoto Azuma.

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Azuma, N., Katada, Y., Nishimura, N. et al. A case of granuloma in the occipital lobe of a patient with Wegener’s granulomatosis. Mod Rheumatol 18, 411–415 (2008). https://doi.org/10.1007/s10165-008-0070-z

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  • DOI: https://doi.org/10.1007/s10165-008-0070-z

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