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A case of Wegener's granulomatosis associated with progressive dysphagia owing to esophageal involvement

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Modern Rheumatology

Abstract

A 52-year-old woman was admitted to our hospital with progressive dysphagia. Upper gastrointestinal endoscopy revealed esophageal stenosis and computed tomographic scan revealed symmetrical wall thickness of the thoracic esophagus. Biopsies findings from a lesion were unremarkable. However, a definitive diagnosis of Wegener's granulomatosis was based on positive anti-neutrophil cytoplasmic antibodies directed against proteinase 3 and otorhinolaryngological manifestations. Esophageal complications are rarely reported in Wegener's granulomatosis; however, clinicians should be aware of the possibility of esophageal involvement.

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References

  1. EW Walton (1958) ArticleTitleGiant-cell granuloma of the respiratory tract (Wegener's granulomatosis) Br Med J 2 265–70 Occurrence Handle13560836 Occurrence Handle1:STN:280:DyaG1c7gtl2nsA%3D%3D Occurrence Handle10.1136/bmj.2.5091.265

    Article  PubMed  CAS  Google Scholar 

  2. GS Hoffman GS Kerr RY Leavitt CW Hallahan RS Lebovics WD Travis et al. (1992) ArticleTitleWegener granulomatosis: an analysis of 158 patients Ann Intern Med 116 488–98 Occurrence Handle1739240 Occurrence Handle1:STN:280:DyaK387lt1Gqsw%3D%3D

    PubMed  CAS  Google Scholar 

  3. M Tokuda N Kurata H Daikuhara M Akisawa I Onishi T Asano et al. (1989) ArticleTitleSmall intestinal perforation in Wegener's granulomatosis J Rheumatol 16 547–9 Occurrence Handle2746597 Occurrence Handle1:STN:280:DyaL1MzhtFehtQ%3D%3D

    PubMed  CAS  Google Scholar 

  4. B Storesund JT Gran W Koldingsnes (1998) ArticleTitleSevere intestinal involvement in Wegener's granulomatosis: report of two cases and review of the literature Br J Rheumatol 37 387–90 Occurrence Handle9619888 Occurrence Handle10.1093/rheumatology/37.4.387 Occurrence Handle1:STN:280:DyaK1c3otFWrtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  5. T Akca T Colak M Caglikulekci K Ocal S Aydin (2005) ArticleTitleIntestinal perforation in Wegener's granulomatosis: a case report Ulus Travma Derg 11 348–51 Occurrence Handle16341975

    PubMed  Google Scholar 

  6. JL Fahey E Leonard J Churg G Godman (1954) ArticleTitleWegener's granulomatosis Am J Med 17 168–79 Occurrence Handle13180525 Occurrence Handle10.1016/0002-9343(54)90255-7 Occurrence Handle1:STN:280:DyaG2c7gtVKrtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  7. RF Spiera DA Filippa MS Bains SA Paget (1994) ArticleTitleEsophageal involvement in Wegener's granulomatosis Arthritis Rheum 37 1404–7 Occurrence Handle7945506 Occurrence Handle10.1002/art.1780370920 Occurrence Handle1:STN:280:DyaK2M%2Fjt1amtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  8. GA Fallows SF Hamilton DS Taylor SB Reddy (2000) ArticleTitleEsophageal involvement in Wegener's granulomatosis: a case report and review of the literature Can J Gastroenterol 14 449–51 Occurrence Handle10851287 Occurrence Handle1:STN:280:DC%2BD3czhtFCkug%3D%3D

    PubMed  CAS  Google Scholar 

  9. S Arista L Sailler L Astudillo (2005) ArticleTitleRelapsing esophageal and gastric ulcers revealing Wegener's granulomatosis Am J Med 118 923–4 Occurrence Handle16084188 Occurrence Handle10.1016/j.amjmed.2004.12.032

    Article  PubMed  Google Scholar 

  10. PG Miller C Santini MJ Freed (2001) ArticleTitleDysphagia in a patient with Wegener's granulomatosis: case report Dysphagia 16 136–9 Occurrence Handle11305224 Occurrence Handle10.1007/s004550110007 Occurrence Handle1:STN:280:DC%2BD3MzlsFWmtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  11. X Bosch A Guilabert J Font (2006) ArticleTitleAntineutrophil cytoplasmic antibodies Lancet 368 404–18 Occurrence Handle16876669 Occurrence Handle10.1016/S0140-6736(06)69114-9 Occurrence Handle1:CAS:528:DC%2BD28XnsFymsbc%3D

    Article  PubMed  CAS  Google Scholar 

  12. H Xiao P Heeringa P Hu Z Liu M Zhao Y Aratani et al. (2002) ArticleTitleAntineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice J Clin Invest 110 955–63 Occurrence Handle12370273 Occurrence Handle10.1172/JCI200215918 Occurrence Handle1:CAS:528:DC%2BD38XnslSksbg%3D

    Article  PubMed  CAS  Google Scholar 

  13. B Storesund JT Gran W Koldingsnes (1998) ArticleTitleSevere intestinal involvement in Wegener's granulomatosis: report of two cases and reviews of the literature Br J Rheumatol 37 387–90 Occurrence Handle9619888 Occurrence Handle10.1093/rheumatology/37.4.387 Occurrence Handle1:STN:280:DyaK1c3otFWrtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  14. AS Fauci BF Haynes P Katz SM Wolff (1983) ArticleTitleWegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years Ann Intern Med 98 76–85 Occurrence Handle6336643 Occurrence Handle1:STN:280:DyaL3s%2FntlSitw%3D%3D

    PubMed  CAS  Google Scholar 

  15. M Gamilleri CD Pusey VS Chadwick AJ Rees (1983) ArticleTitleGastrointestinal manifestations of systemic vasculitis Q J Med 52 141–9

    Google Scholar 

  16. JC Jennette JR Hoidal RJ Falk (1990) ArticleTitleSpecificity of anti-neutrophil cytoplasmic autoantibodies for proteinase 3 Blood 75 2263–4 Occurrence Handle2189509 Occurrence Handle1:STN:280:DyaK3c3mvVWitg%3D%3D

    PubMed  CAS  Google Scholar 

  17. S Bakthavachalam MS Driver C Cox JH Spiegel KM Grundfast (2004) ArticleTitleHearing loss in Wegener's granulomatosis Otol Neurotol 25 833–7 Occurrence Handle15354019 Occurrence Handle10.1097/00129492-200409000-00030

    Article  PubMed  Google Scholar 

  18. S Gottschlich P Ambrosch D Kramkowski M Laudien T Buchelt WL Gross et al. (2006) ArticleTitleHead and neck manifestations of Wegener's granulomatosis Rhinology 44 227–33 Occurrence Handle17216737 Occurrence Handle1:STN:280:DC%2BD2s%2FitFanug%3D%3D

    PubMed  CAS  Google Scholar 

  19. Y Manchanda T Tejasvi R Handa M Ramam (2003) ArticleTitleStrawberry gingival: a distinctive sign in Wegener's granulomatosis J Am Acad Dermatol 49 335–7 Occurrence Handle12894093 Occurrence Handle10.1067/S0190-9622(03)00556-5

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Osaka City Juso Hospital, 2-12-27 Nonaka-kita, Yodogawa-ku, Osaka, 532-0034, Japan

    Toshimasa Yamaguchi

  2. Department of Internal Medicine, Osaka City General Hospital, Osaka, Japan

    Katsunobu Yoshioka, Mami Ueda, Takashi Morikawa, Keiko Yamagami, Yoshio Konishi, Toshihiko Sato & Masahito Imanishi

  3. Department of Gastroenterology, Osaka City General Hospital, Osaka, Japan

    Yasuko Kawasaki

Authors
  1. Toshimasa Yamaguchi
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  2. Katsunobu Yoshioka
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  3. Mami Ueda
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  4. Takashi Morikawa
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  5. Keiko Yamagami
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  6. Yoshio Konishi
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  7. Toshihiko Sato
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  8. Yasuko Kawasaki
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  9. Masahito Imanishi
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Corresponding author

Correspondence to Toshimasa Yamaguchi.

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Yamaguchi, T., Yoshioka, K., Ueda, M. et al. A case of Wegener's granulomatosis associated with progressive dysphagia owing to esophageal involvement. Mod Rheumatol 17, 521–525 (2007). https://doi.org/10.1007/s10165-007-0633-4

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  • DOI: https://doi.org/10.1007/s10165-007-0633-4

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