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Primary biliary cirrhosis in female subjects with sicca-associated antibodies

  • ORIGINAL ARTICLE
  • Published:
Modern Rheumatology

Abstract

The aim of this study is to clarify the time course of primary biliary cirrhosis (PBC) in subjects possessing anticentromere antibodies (ACA), anti-Ro, and/or anti-La antibodies, and who used alkaline phosphatase (ALP) as a serological marker for PBC. Female subjects (n = 165), who had at least one of ACA, anti-Ro, and/or anti-La, were enrolled in this study. Groups A (ACA alone, n = 44), B (anti-Ro alone, n = 54), E (anti-Ro and anti-La, n = 52), and DFG (ACA with anti-Ro and/or anti-La, n = 14) were analyzed. Healthy females (n = 65) were used as a control. The frequencies of the PBC in groups A (13.6%) and DFG (14.3%) were higher than those in groups B (1.9%) and E (0.0%). The ALP levels increased with age in groups A and DFG and slightly increased with age in groups B and C, and the control group. After correcting for age by analysis of covariance, a comparison of ALP levels among the groups not having anti-M2 was as follows: group A ≒ group DFG > group B ≒ group E ≒ the control group. The subjects with ACA might thus have PBC more frequently than either those with anti-Ro and/or anti-La, or the control subjects.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Rheumatology, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Japan

    Kunio Takada, Kimihiro Suzuki, Mitsuyo Matsumoto, Makoto Okada, Takashi Nakanishi, Hideyuki Horikoshi, Tomoaki Higuchi & Fumitaka Ohsuzu

Authors
  1. Kunio Takada
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  2. Kimihiro Suzuki
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  3. Mitsuyo Matsumoto
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  4. Makoto Okada
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  5. Takashi Nakanishi
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  6. Hideyuki Horikoshi
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  7. Tomoaki Higuchi
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  8. Fumitaka Ohsuzu
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Correspondence to Kunio Takada.

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Takada, K., Suzuki, K., Matsumoto, M. et al. Primary biliary cirrhosis in female subjects with sicca-associated antibodies. Mod Rheumatol 17, 486–491 (2007). https://doi.org/10.1007/s10165-007-0631-6

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  • DOI: https://doi.org/10.1007/s10165-007-0631-6

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