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A case of proteinase 3-antineutrophil cytoplasmic antibody-positive Sjögren's syndrome complicated with interstitial nephritis

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Modern Rheumatology

Abstract

A 65-year-old woman who had fever was admitted. Laboratory data showed renal tubular dysfunction, elevated C-reactive protein, soluble interleukin-2 receptor (sIL-2R), and IgG. Her blood showed proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA) as well as antinuclear antibody and anti-Ro/SS-A antibody. Salivary gland and renal biopsy showed inflammatory infiltration of lymphocytes. A diagnosis of Sjögren's syndrome (SS) and interstitial nephritis was made. β2-microglobulin, sIL-2R, IgG, and PR3-ANCA were decreased in response to medium-dose oral prednisolone. Antineutrophil cytoplasmic antibody could be a new marker for extraglandular features of SS. It would be beneficial for SS patients who have positive ANCA to investigate extraglandular lesions such as interstitial nephritis.

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Authors and Affiliations

  1. Third Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan

    Kumiko Shimoyama, Noriyoshi Ogawa, Yoshiaki Dei, Daisuke Suzuki, Miwako Saito & Hideharu Hayashi

Authors
  1. Kumiko Shimoyama
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  2. Noriyoshi Ogawa
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  3. Yoshiaki Dei
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  4. Daisuke Suzuki
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  5. Miwako Saito
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  6. Hideharu Hayashi
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Correspondence to Kumiko Shimoyama.

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Shimoyama, K., Ogawa, N., Dei, Y. et al. A case of proteinase 3-antineutrophil cytoplasmic antibody-positive Sjögren's syndrome complicated with interstitial nephritis. Mod Rheumatol 17, 514–517 (2007). https://doi.org/10.1007/s10165-007-0621-8

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  • DOI: https://doi.org/10.1007/s10165-007-0621-8

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