Abstract
A 68-year-old man with a 3-year history of rheumatoid arthritis (RA) developed gynecomastia 3 months after beginning oral low-dose methotrexate (MTX) therapy. Four months after MTX therapy was discontinued, the gynecomastia symptoms improved. Only eight cases of gynecomastia resulting from low-dose MTX administration have been reported worldwide, and no cases have previously been reported in Japan. Although it occurs infrequently, gynecomastia resulting from low-dose MTX therapy should be considered in male patients with RA.
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Abe, K., Mitsuka, T., Kanamori, S. et al. Gynecomastia associated with low-dose methotrexate therapy for rheumatoid arthritis. Mod Rheumatol 17, 511–513 (2007). https://doi.org/10.1007/s10165-007-0619-2
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DOI: https://doi.org/10.1007/s10165-007-0619-2