Modern Rheumatology

, Volume 15, Issue 1, pp 37–40 | Cite as

Doppler sonographic evaluation of effect of treatment with infliximab (Remicade) for rheumatoid arthritis

  • Atsushi Takahashi
  • Ai Sato
  • Yukio Yamadera
  • Isao Takeda
  • Takashi Kanno
  • Yoshito Ohguchi
  • Tomoe Nishimaki
  • Reiji Kasukawa
ORIGINAL ARTICLE

Abstract

Synovial vascularization in the knee joints of six patients with rheumatoid arthritis who were treated with infliximab was evaluated by Doppler sonography. Power Doppler sonography demonstrated a significant reduction of color flow signals (P < 0.05), and spectral Doppler sonography demonstrated a significant increase in vascular resistance (P < 0.05) at week 6 (after three injections) evaluation of the therapy. A significant decrease in the number of tender joints (P < 0.05) and C-reactive protein value (P < 0.05) was also observed in these patients.

Key words

Doppler sonography Infliximab Resistive index (RI) Rheumatoid arthritis (RA) Synovial vascularization 

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Copyright information

© Japan College of Rheumatology and Springer-Verlag Tokyo 2005

Authors and Affiliations

  • Atsushi Takahashi
    • 1
  • Ai Sato
    • 1
  • Yukio Yamadera
    • 2
  • Isao Takeda
    • 1
  • Takashi Kanno
    • 1
  • Yoshito Ohguchi
    • 3
  • Tomoe Nishimaki
    • 4
  • Reiji Kasukawa
    • 1
  1. 1.Division of RheumatologyOhta Nishinouchi HospitalKoriyamaJapan
  2. 2.Physiological Examination UnitOhta Nishinouchi HospitalKoriyamaJapan
  3. 3.Ohguchi ClinicKoriyamaJapan
  4. 4.Nishimaki ClinicSukagawaJapan
  5. 5.Second Department of Internal MedicineFukushima Medical University, School of MedicineFukushimaJapan

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