Doppler sonographic evaluation of effect of treatment with infliximab (Remicade) for rheumatoid arthritis
Synovial vascularization in the knee joints of six patients with rheumatoid arthritis who were treated with infliximab was evaluated by Doppler sonography. Power Doppler sonography demonstrated a significant reduction of color flow signals (P < 0.05), and spectral Doppler sonography demonstrated a significant increase in vascular resistance (P < 0.05) at week 6 (after three injections) evaluation of the therapy. A significant decrease in the number of tender joints (P < 0.05) and C-reactive protein value (P < 0.05) was also observed in these patients.
Key wordsDoppler sonography Infliximab Resistive index (RI) Rheumatoid arthritis (RA) Synovial vascularization
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