Abstract
We report a case of marked hypocomplementemia and tubulointerstitial nephritis associated with SjÖgren’s syndrome (SS) in a male patient. Renal biopsy revealed tubulointerstitial nephritis but did not identify specific immune deposits of the tubulointerstitium. After steroid therapy, the renal failure and hypocomplementemia diminished. Hypocomplementemia without cryoglobulinemia is not commonly observed in SS patients, and hypocomplementemic tubulointerstitial nephritis was strongly suspected. Hypocomplementemic tubulointerstitial nephritis is rare; only one case has been described in the literature. In our case and the previous case, the patients were elderly men, and they had some similar clinical characteristics. Idiopathic hypocomplementemic tubulointerstitial nephritis resembling our case has been reported. These facts suggest that hypocomplementemic tubulointerstitial nephritis may occur in patients with SS, and such cases may not be as rare as once thought because it might be appropriate to include them in the category of idiopathic cases. Such a syndrome should be included in the differential diagnosis of hypocomplementemia.
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Yukawa, N., Tsuboi, N., Yukawa, S. et al. Marked hypocomplementemia and tubulointerstitial nephritis in a male patient with SjÖgren’s syndrome. Mod Rheumatol 14, 164–168 (2004). https://doi.org/10.1007/s10165-004-0285-6
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DOI: https://doi.org/10.1007/s10165-004-0285-6